| State: | MO |
| Type: | Route |
| Route: | 105 |
| Established: | 1930 |
| Length Mi: | 10.534 |
| Direction A: | South |
| Terminus A: | in East Prairie |
| Direction B: | North |
| Junction: | in Charleston |
| Terminus B: | in Charleston |
| Previous Type: | MO |
| Previous Route: | 104 |
| Next Type: | MO |
| Next Route: | 106 |
| Map Custom: | yes |
| Map Notes: | MO 105 highlighted in red |
Route 105 is a highway in Mississippi County, Missouri. Its northern terminus is at Interstate 57/U.S. Route 60 in Charleston; its southern terminus is at Route 80 in East Prairie. Other than the two termini, no other towns are on the route.
In 1924, Route 55 was designated along a concrete road starting from Benton to Wolf Island.[1] A spur of Route 55, Route 55A, was designated one year later to a concrete road. Its western terminus was at the New Madrid–Mississippi county line, and its eastern terminus was at Route 55 north of East Prairie.[2]