| State: | MS |
| Type: | MS |
| Route: | 355 |
| Map Custom: | yes |
| Maint: | Pontotoc County and MDOT |
| Length Mi: | 11.931 |
| Length Ref: | [1] |
| Established: | 1957 |
| Direction A: | South |
| Terminus A: | near Thaxton |
| Direction B: | North |
| Terminus B: | near New Albany |
| Counties: | Pontotoc, Union |
| Previous Type: | MS |
| Previous Route: | 354 |
| Next Type: | MS |
| Next Route: | 356 |
Mississippi Highway 355 (MS 355) is a 11.9adj=midNaNadj=mid north–south state highway in Pontotoc and Union counties. It connects the town of Thaxton with the town of New Albany.
The entire length of MS 355 is a rural, two-lane, state highway.
MS 355 begins at an intersection with MS 346 in the community of Esperanza, north of Thaxton in Pontotoc County. The highway at this point is unsigned; it is not maintained by the state, rather by Pontotoc County as unsigned County Road 858 (CR 858).[1] [2] The road heads northwest, then north intersecting minor county roads and crossing Mill Creek as it passes through mostly agricultural fields. At the Pontotoc-Union county line, state maintenance and signage for MS 355 begins. The highway generally continues northwest through woods and farm fields. At Union CR 47, MS 355 reaches a T-intersection; MS 355 heads due west from this intersection. It later curves to the north passing through the community of Etta before ending at MS 30.