| State: | MS |
| Type: | MS |
| Route: | 301 |
| Map Custom: | yes |
| Maint: | none |
| Length Mi: | 23.336 |
| Length Ref: | [1] [2] |
| Direction A: | South |
| Terminus A: | near Arkabutla |
| Junction: | |
| Direction B: | North |
| Terminus B: | at the Tennessee state line near Memphis |
| Established: | 1950 |
| Counties: | Tate, DeSoto |
| Previous Type: | US |
| Previous Route: | 278 |
| Next Type: | MS |
| Next Route: | 302 |
Mississippi Highway 301 (MS 301) is a north-south state highway in northwestern Mississippi. It runs from the community of Arkabutla in Tate County, north across Arkabutla Dam, to the Tennessee border in DeSoto County, where it continues as Tennessee State Route 175 (SR 175 / Weaver Road).
In Tate County, MS 301 begins at an intersection between Arkabutla Road and MS 304 Scenic in the community of Arkabutla. It travels northward, concurrent with MS 304 Scenic, through farmland to leave the community and wind its way through hilly woodlands for a few miles to pass along the shores of Sunfish Bay (part of Arkabutla Lake). The highway now passes along the western side of the Arkabutla Dam, where it crosses a bridge over the Coldwater River into DeSoto County. Officially, the MS 301 designation is discontinued across the foot of the dam but no signage for MS 301 appears along the road south of the dam.[1]
MS 301/MS 304 Scenic now leaves the Dam area as they turn left onto Pratt Road and head west. They then cross Cub Lake Bayou before making a right turn and heading north again. They pass through the community of Eudora, where the road intersects the former alignment of MS 304. The concurrency with MS 304 ends as it travels eastward at the intersection. At this point, signage for MS 301 begins and the highway becomes maintained by the state after having been locally maintained to the south.[2] MS 301 has an intersection with Green River Road, the route meets current MS 304 and Interstate 69 (I-69) at a diamond interchange (unnumbered exit). Past the interchange, MS 301 turns northeastward and it passes through the community of West Days at Days Road. At the intersection with Church Road, MS 301 widens to 5 lanes. The route intersects MS 302 in Lynchburg and continues northwards to the state line. MS 301 ends at the state line, and Tennessee State Route 175 (SR 175) continues past that point into the city of Memphis.