| Winner: | Ana María Ortíz Mendoza |
| Represented: | Puerto Plata |
| Date: | January 24, 1968 |
| Venue: | La Concha Acústica del Hotel Embajador, Santo Domingo, Dominican Republic |
| Next Pageant: | Miss Universe 1968 |
| Broadcaster: | Color Vision |
| Entrants: | 24 |
Señorita República Dominicana 1968 was held on January 24, 1968. There were 24 candidates who competed for the national crown. The winner represented the Dominican Republic at the Miss Universe 1968. The Virreina al Miss Mundo entered Miss World 1968. Only 25 provinces and one municipality entered. The top 10 wore their evening gowns and answered questions so they could go to the top from which five were selected.