| Winner: | Jeanette Dotel Montes de Ocoa |
| Represented: | San Juan de la Maguana |
| Date: | September 30, 1966 |
| Venue: | La Concha Acústica del Hotel Embajador, Santo Domingo, Dominican Republic |
| Next Pageant: | Miss World 1966 |
| Broadcaster: | Color Vision |
| Entrants: | 26 |
Señorita República Dominicana Mundo 1966 was held on September 30, 1966. There were 26 candidates who competed for the national crown. The winner represented the Dominican Republic at Miss World 1966. The top 10 showed their evening gowns and answered questions to advance to the top 5, where they answered more questions.