| Misiliscemi | |
| Official Name: | Comune di Misiliscemi |
| Coordinates: | 37.8852°N 12.6353°W |
| Region: | Sicily |
| Province: | Trapani (TP) |
| Established Date: | 20 February 2021 |
| Frazioni: | Fontanasalsa, Guarrato, Rilievo, Locogrande, Marausa, Palma, Salinagrande, Pietretagliate |
| Mayor: | Carmelo Burgio (Commissario straordinario)(since 16 April 2021)[1] |
| Area Total Km2: | 93 |
| Elevation M: | 16 |
| Population Total: | 8669 |
| Population As Of: | 2021 |
| Population Demonym: | Misilesi |
| Postal Code: | 91100 |
| Area Code: | 0923 |
| Istat: | 081025 |
Misiliscemi is a comune in Sicily, Italy, administratively part of the province of Trapani. It borders the municipalities of Marsala, Paceco and Trapani.
It was formed in 2021 as result of the 2018 referendum, in which the inhabitants of the eight frazioni of Trapani voted for the formation of Misiliscemi, with 3,752 votes in favor out of 7,530 voters.[2]
The comune is named after a river which arose in it.[3] The term derives from Masil Escemmu,[4] which is in turn derived from the Arabic which means "High place where the water flows".[5]