| Birth Date: | 20 April 1927 |
| Birth Place: | Kondoli, Georgian SSR, Soviet Union |
| Death Date: | 3 August 2000 (aged 73) |
| Death Place: | Telavi, Georgia |
| Sport: | Freestyle wrestling |
| Club: | Spartak Tbilisi |
| Show-Medals: | yes |
Mirian Tsalkalamanidze (Georgian: მირიან ცალქალამანიძე, 20 April 1927 – 3 August 2000) was a Georgian flyweight freestyle wrestler. He competed for the Soviet Union at the 1956 Olympics and won a gold medal in the 52 kg division. At the world championships he placed third in 1954 and second in 1957.
Tsalkalamanidze initially trained in chidaoba, the Georgian traditional wrestling, and changed to freestyle wrestling only in 1951, aged 24. He won the Soviet freestyle championships in 1954 in 1956, placing third in 1955.