Miriam Rossi (chemist) explained

Miriam Rossi
Alma Mater:Hunter College
Johns Hopkins University (PhD)
Thesis Title:Hydrogen bonding, stacking and metal ion interactions in pyrimidine derivatives : some structural studies
Thesis Url:https://www.worldcat.org/oclc/4859947
Thesis Year:1978
Workplaces:Vassar College
Notable Students:Cathy Drennan
Academic Advisors:Jenny Glusker

Miriam Rossi is an Italian-American chemist and the Mary Landon Sague Chair at Vassar College. She works on x-ray crystallography and chemistry education.

Early life and education

Rossi was born in Italy and moved to New York City as a child. She studied chemistry at Hunter College, where she worked with David Beveridge. She was the first in her family to have attained a PhD degree. In fact, her parents, in Italy, had a 4th grade education, the maximum available at the time. Her older brother, Egidio Rossi, is a nephrologist in Parma, Italy. She joined Johns Hopkins University for her doctoral studies, earning a PhD in inorganic chemistry under the supervision of Tom Kistenmacher. She worked on the refinement of 1-methylcytosine.[1]

Research and career

Rossi joined the Fox Chase Cancer Center as a postdoctoral fellow with Jenny Glusker. Here she determined the structure of methylcobalamin, an active compound of Vitamin B12.[2]

In 1982 Rossi joined Vassar College.[3] She uses X-ray crystallography to study the structure and function of molecules, particularly those with biological activity.[4] She has investigated several biological molecules, including quercetin, curcumin and resveratrol.[5] [6] Rossi identified the bioactivity of curcumin.[7] At Vassar College, Rossi supervised Cathy Drennan, and has continued to act as her mentor.[8] [9] She served on the US National Committee for Crystallography and is currently a member of the International Union of Crystallography Commission on Education.

Rossi has been involved with teaching crystallography and chemistry throughout her academic career.[10] She is responsible for teaching structural chemistry and biochemistry. At Vassar she led the Culture and Chemistry of Cuisine course.[11] In the class, students learn about fermentation, leavening and the behaviour of starches. She has worked with The Culinary Institute of America on their culinary science program.[12] After being asked to speak about the nutritional benefits of the Mediterranean diet, Rossi became interested in the scientific origins. She collaborated with an olive oil producer in California and found that olive oil limited the growth of tumour cells and had strong antioxidant properties.[13] [14] Working with undergraduate students from Vassar College, Rossi investigated the health improving properties of goji berries; using X-ray diffraction to determine the structure of β-ionone, emodin and cnidium.[15] She also looked at hispolon, a compound that is found in mushrooms from East Asia. She was made the Mary Landon Sague Professor of Chemistry in 2008.[16]

Rossi worked on initiatives to advance women faculty memberships into leadership positions.[17] She has developed mentoring schemes and cyber networking opportunities. She looked at horizontal peer mentoring for senior women at liberal arts colleges. In 2017 Rossi was named at the Diamond Level of the Mid-Hudson section of the American Chemical Society.[18]

Publications

Notes and References

  1. Kistenmacher. T. J.. Rossi. M.. 1977-12-15. 1-Methylcytosine: a refinement. Acta Crystallographica Section B. 33. 12. 3962–3965. 10.1107/S0567740877012618. 0567-7408.
  2. Web site: Jenny Pickworth Glusker. www.amercrystalassn.org. 2019-02-09.
  3. Web site: Women in Science at Columbia. Columbia. 2019-02-09.
  4. Web site: Miriam Rossi - Faculty - Vassar College. www.vassar.edu. 2019-02-09.
  5. Web site: Miriam Rossi. 2019-02-09.
  6. Rossi. Miriam. Rickles. Lori F.. Halpin. Wendy A.. 1986-03-01. The crystal and molecular structure of quercetin: A biologically active and naturally occurring flavonoid. Bioorganic Chemistry. 14. 1. 55–69. 10.1016/0045-2068(86)90018-0. 0045-2068.
  7. Caruso. Francesco. Monti. Elena. Matthews. Julian. Rossi. Miriam. Gariboldi. Marzia Bruna. Pettinari. Claudio. Pettinari. Riccardo. Marchetti. Fabio. 2014-04-07. Synthesis, Characterization, and Antitumor Activity of Water-Soluble (Arene)ruthenium(II) Derivatives of 1,3-Dimethyl-4-acylpyrazolon-5-ato Ligands. First Example of Ru(arene)(ligand) Antitumor Species Involving Simultaneous Ru–N7(guanine) Bonding and Ligand Intercalation to DNA. Inorganic Chemistry. 53. 7. 3668–3677. 10.1021/ic403170y. 24611608. 0020-1669.
  8. Web site: Catherine L Drennan Drennan Lab. drennan.mit.edu. 2019-02-09.
  9. Web site: Section Head profile: Cathy Drennan - F1000 BlogsF1000 Blogs. blog.f1000.com. 2019-02-09.
  10. Rossi. Miriam. Berman. Helen M.. 1988. Introduction. Journal of Chemical Education. 65. 6. 472. 10.1021/ed065p472. 1988JChEd..65..472R. 0021-9584. free.
  11. Web site: Chem Class Cuisine at Vassar College. Barrett. Peter. Chronogram Magazine. 2019-02-09.
  12. Web site: Students "Science It Up" at the CIA with Final Projects. 2017-01-11. CIA Culinary School Blog. 2019-02-09.
  13. Incerpi. Sandra. Pedersen. Jens. Tofani. Daniela. Filipský. Tomáš. Leone. Stefano. Raley-Susman. Kathleen M.. Molasky. Nora. Belli. Stuart L.. Candelotti. Elena. 2017-12-28. Protection by extra virgin olive oil against oxidative stress in vitro and in vivo. Chemical and biological studies on the health benefits due to a major component of the Mediterranean diet. PLOS ONE. 12. 12. e0189341. 10.1371/journal.pone.0189341. 1932-6203. 5746230. 29283995. 2017PLoSO..1289341R. free.
  14. Web site: The Case for Extra Virgin Olive Oil - Vassar and Italian Scientists Prove Its Benefits. Vassar College. 2019-02-09.
  15. Web site: The Science behind Centuries of Traditional Medicines. Vassar College. 2019-02-09.
  16. Web site: COLLABORATIVE RESEARCH FOR HORIZONTAL MENTORING ALLIANCES. HMC. 2019-02-09.
  17. Web site: NSF Award Search: Award#0618940 - ADVANCE Partnerships for Adaptation, Implementation, and Dissemination Award: Collaborative Research for Horizontal Mentoring Alliances. www.nsf.gov. 2019-02-09.
  18. Web site: Other Recognition. Mid-Hudson SectionAmerican Chemical Society. 2019-02-09.