| Cabinet Name: | Mirek Topolánek's First Cabinet |
| Cabinet Number: | 8th |
| Jurisdiction: | Czech Republic |
| Flag: | Coat of arms of the Czech Republic.svg |
| Incumbent: | 4 September 2006 - 9 January 2007 |
| Date Formed: | 4 September 2006 |
| Date Dissolved: | 9 January 2007 |
| Government Head: | Mirek Topolánek |
| State Head: | Václav Klaus |
| Current Number: | 15 |
| Political Party: | ODS |
| Legislature Status: | Minority |
| Opposition Party: | ČSSD KSČM KDU-ČSL SZ |
| Opposition Leader: | Jiří Paroubek |
| Election: | 2006 Czech legislative election |
| Incoming Formation: | 2006 |
| Outgoing Formation: | 2007 |
| Previous: | Cabinet of Jiří Paroubek |
| Successor: | Second Cabinet of Mirek Topolánek |
Mirek Topolánek's First Cabinet was Cabinet of the Czech Republic from 4 September 2006 to 9 January 2007. The cabinet consisted of members of Civic Democratic Party (ODS) and non-partisans. On 3 October 2006 the cabinet did not pass through Confidence and supply in Chamber of Deputies of the Parliament of the Czech Republic by 96 to 99.
| Portfolio | Minister | Political party | In office | |
|---|---|---|---|---|
| Prime Minister | Mirek Topolánek | ODS | 16 August 2006 - 9 January 2007 | |
| Deputy Prime Minister and Minister of Labour and Social Affairs | Petr Nečas | ODS | 4 September 2006 - 9 January 2007 | |
| Minister of the Interior and Minister of Informatics | Ivan Langer | ODS | 4 September 2006 - 9 January 2007 | |
| Minister of Justice and Chairman of the Legislative Council | Jiří Pospíšil | ODS | 4 September 2006 - 9 January 2007 | |
| Minister of Foreign Affairs | Alexandr Vondra | non-partisan | 4 September 2006 - 9 January 2007 | |
| Minister of Defence | Jiří Šedivý | non-partisan | 4 September 2006 - 9 January 2007 | |
| Minister of Finance | Vlastimil Tlustý | ODS | 4 September 2006 - 9 January 2007 | |
| Minister of Transport | Aleš Řebíček | ODS | 4 September 2006 - 9 January 2007 | |
| Minister of Industry and Trade | Martin Říman | ODS | 4 September 2006 - 9 January 2007 | |
| Minister of Agriculture | Milena Vicenová | non-partisan | 4 September 2006 - 9 January 2007 | |
| Minister of Health | Tomáš Julínek | ODS | 4 September 2006 - 9 January 2007 | |
| Minister of Education, Youth and Sport | Miroslava Kopicová | non-partisan | 4 September 2006 - 9 January 2007 | |
| Minister of the Environment | Petr Kalaš | non-partisan | 4 September 2006 - 9 January 2007 | |
| Minister of Culture | Martin Štěpánek | non-partisan | 4 September 2006 - 9 January 2007 | |
| Minister for Regional Development | Petr Gandalovič | ODS | 4 September 2006 - 9 January 2007 |