Mir-663 microRNA precursor family explained

mir-663
Symbol:	mir-663
Rfam:	RF00957
Mirbase Family:	MIPF0000462
Rna Type:	microRNA
Tax Domain:	Eukaryota

In molecular biology mir-663 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Gastric cancer suppression

miR-663 has been identified as a possible suppressor of tumour growth, with its levels downregulated in human gastric cancer cell lines. Its introduction into the two human gastric cancer cell lines BGC823 and SNU5 induces morphology changes and suppresses cell proliferation.^[1] Transfection with miR-663 also sees a resultant upregulation of cyclin B.

miR-155 upregulation and other molecular targets

Resveratrol, a natural phenol and antioxidant, upregulates miR-663 in human THP-1 monocytic cells, human blood monocytes and MCF7 brest cancer cells.^[2] Endogenous activator protein-1 (AP-1) activity is decreased by miR-663 and there is additional impaired lipopolysaccharide upregulation. miR-663 directly targets JunD and JunB transcripts, and alters AP-1 upregulation through this. It is further involved in the impaired lipopolysaccharide upregulation of miR-155 by resveratrol.^[3] miR-663 also directly targets EEF1A2, translation elongation factor and well-known protooncogene.^{[2] [4]}

See also

• MicroRNA

Further reading

• Liang P, Lv C, Jiang B, Long X, Zhang P, Zhang M, Xie T, Huang X . MicroRNA profiling in denatured dermis of deep burn patients . Burns . 38 . 4 . 534–40 . June 2012 . 22360957 . 10.1016/j.burns.2011.10.014 .
• Lu J, Kwan BC, Lai FM, Tam LS, Li EK, Chow KM, Wang G, Li PK, Szeto CC . Glomerular and tubulointerstitial miR-638, miR-198 and miR-146a expression in lupus nephritis . Nephrology . 17 . 4 . 346–51 . May 2012 . 22295894 . 10.1111/j.1440-1797.2012.01573.x . 24163790 .
• Yi C, Wang Q, Wang L, Huang Y, Li L, Liu L, Zhou X, Xie G, Kang T, Wang H, Zeng M, Ma J, Zeng Y, Yun JP . MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma . Oncogene . 31 . 41 . 4421–33 . October 2012 . 22249270 . 10.1038/onc.2011.629 . free .
• Yang Y, Wang LL, Li YH, Gao XN, Liu Y, Yu L . Effect of CpG island methylation on microRNA expression in the k-562 cell line . Biochemical Genetics . 50 . 1–2 . 122–34 . February 2012 . 22089542 . 10.1007/s10528-011-9478-9 . 16736093 .
• Marques FZ, Campain AE, Tomaszewski M, Zukowska-Szczechowska E, Yang YH, Charchar FJ, Morris BJ . Gene expression profiling reveals renin mRNA overexpression in human hypertensive kidneys and a role for microRNAs . Hypertension . 58 . 6 . 1093–8 . December 2011 . 22042811 . 10.1161/HYPERTENSIONAHA.111.180729 . free .
• Borgan E, Navon R, Vollan HK, Schlichting E, Sauer T, Yakhini Z, Lingjærde OC, Sørlie T, Børresen-Dale AL . Ischemia caused by time to freezing induces systematic microRNA and mRNA responses in cancer tissue . Molecular Oncology . 5 . 6 . 564–76 . December 2011 . 21917534 . 5528325 . 10.1016/j.molonc.2011.08.004 .
• Tili E, Michaille JJ . Resveratrol, MicroRNAs, Inflammation, and Cancer . Journal of Nucleic Acids . 2011 . 102431 . 2011 . 21845215 . 3154569 . 10.4061/2011/102431 . free .
• Yang Y, Wang LL, Li YH, Gao XN, Yu L . [Expression level of miRNA-663 in different leukemic cell lines and its biological function] . Zhongguo Shi Yan Xue Ye Xue Za Zhi . 19 . 2 . 279–83 . April 2011 . 21518471 .
• Jian P, Li ZW, Fang TY, Jian W, Zhuan Z, Mei LX, Yan WS, Jian N . Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663 . Journal of Hematology & Oncology . 4 . 20 . April 2011 . 21518431 . 3094392 . 10.1186/1756-8722-4-20 . free .
• Ni CW, Qiu H, Jo H . MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells . American Journal of Physiology. Heart and Circulatory Physiology . 300 . 5 . H1762-9 . May 2011 . 21378144 . 3094086 . 10.1152/ajpheart.00829.2010 .
• Potapova A, Albat C, Hasemeier B, Haeussler K, Lamprecht S, Suerbaum S, Kreipe H, Lehmann U . Systematic cross-validation of 454 sequencing and pyrosequencing for the exact quantification of DNA methylation patterns with single CpG resolution . BMC Biotechnology . 11 . 6 . January 2011 . 21235780 . 3032674 . 10.1186/1472-6750-11-6 . free .
• Liu ZY, Zhang GL, Wang MM, Xiong YN, Cui HQ . MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation . Asian Pacific Journal of Cancer Prevention . 12 . 11 . 2819–23 . 2011 . 22393947 .
• Dreher A, Rossing M, Kaczkowski B, Nielsen FC, Norrild B . Differential expression of cellular microRNAs in HPV-11 transfected cells. An analysis by three different array platforms and qRT-PCR . Biochemical and Biophysical Research Communications . 403 . 3–4 . 357–62 . December 2010 . 21078297 . 10.1016/j.bbrc.2010.11.035 .
• Tili E, Michaille JJ, Alder H, Volinia S, Delmas D, Latruffe N, Croce CM . Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFβ signaling pathway in SW480 cells . Biochemical Pharmacology . 80 . 12 . 2057–65 . December 2010 . 20637737 . 3918904. 10.1016/j.bcp.2010.07.003 .
• Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, Ferracin M, Delmas D, Latruffe N, Croce CM . Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD . Carcinogenesis . 31 . 9 . 1561–6 . September 2010 . 20622002 . 4647642 . 10.1093/carcin/bgq143 .
• Marasa BS, Srikantan S, Martindale JL, Kim MM, Lee EK, Gorospe M, Abdelmohsen K . MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence . Aging . 2 . 6 . 333–43 . June 2010 . 20606251 . 2919253 . 10.18632/aging.100159 .
• Te JL, Dozmorov IM, Guthridge JM, Nguyen KL, Cavett JW, Kelly JA, Bruner GR, Harley JB, Ojwang JO . Identification of unique microRNA signature associated with lupus nephritis . PLOS ONE . 5 . 5 . e10344 . May 2010 . 20485490 . 2867940 . 10.1371/journal.pone.0010344 . 2010PLoSO...510344T . Means . Terry . free .
• Buratti E, De Conti L, Stuani C, Romano M, Baralle M, Baralle F . Nuclear factor TDP-43 can affect selected microRNA levels . The FEBS Journal . 277 . 10 . 2268–81 . May 2010 . 20423455 . 10.1111/j.1742-4658.2010.07643.x . free .
• Maes OC, Sarojini H, Wang E . Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts . Journal of Cellular Physiology . 221 . 1 . 109–19 . October 2009 . 19475566 . 10.1002/jcp.21834 . 21566082 .
• Pizzimenti S, Ferracin M, Sabbioni S, Toaldo C, Pettazzoni P, Dianzani MU, Negrini M, Barrera G . MicroRNA expression changes during human leukemic HL-60 cell differentiation induced by 4-hydroxynonenal, a product of lipid peroxidation . Free Radical Biology & Medicine . 46 . 2 . 282–8 . January 2009 . 19022373 . 10.1016/j.freeradbiomed.2008.10.035 .
• Lehmann U, Hasemeier B, Römermann D, Müller M, Länger F, Kreipe H . [Epigenetic inactivation of microRNA genes in mammary carcinoma] . Verhandlungen der Deutschen Gesellschaft für Pathologie . 91 . 214–20 . 2007 . 18314617 .
• Lehmann U, Hasemeier B, Christgen M, Müller M, Römermann D, Länger F, Kreipe H . Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer . The Journal of Pathology . 214 . 1 . 17–24 . January 2008 . 17948228 . 10.1002/path.2251 . 22024957 .

Notes and References

1. Pan J, Hu H, Zhou Z, Sun L, Peng L, Yu L, Sun L, Liu J, Yang Z, Ran Y . Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells . Oncology Reports . 24 . 1 . 105–12 . July 2010 . 20514450 . 10.3892/or_00000834 . free .
2. Vislovukh A, Kratassiouk G, Porto E, Gralievska N, Beldiman C, Pinna G, El'skaya A, Harel-Bellan A, Negrutskii B, Groisman I . Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744 . British Journal of Cancer . 108 . 11 . 2304–11 . June 2013 . 23695020 . 3681015 . 10.1038/bjc.2013.243 .
3. Tili E, Michaille JJ, Adair B, Alder H, Limagne E, Taccioli C, Ferracin M, Delmas D, Latruffe N, Croce CM . Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD . Carcinogenesis . 31 . 9 . 1561–6 . September 2010 . 20622002 . 4647642 . 10.1093/carcin/bgq143 .
4. Anand N, Murthy S, Amann G, Wernick M, Porter LA, Cukier IH, Collins C, Gray JW, Diebold J, Demetrick DJ, Lee JM . Protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer . Nature Genetics . 31 . 3 . 301–5 . July 2002 . 12053177 . 10.1038/ng904 . 37997742 .