Mir-592 microRNA precursor family explained
| mir-592 |
| Symbol: | mir-592 |
| Rfam: | RF00877 |
| Mirbase Family: | MIPF0000340 |
| Rna Type: | microRNA |
| Tax Domain: | Eukaryota
|
In molecular biology mir-592 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
Expression in cancers
Significantly altered expression of miR-592 has been observed between tumours deficient and proficient for mismatch repair in colon cancer.[1] Expression levels are lower in the proficient form compared to the deficient, with a more than two-fold change.[2] This altered expression has been proposed to reflect a reversion to regulatory programs seen in earlier undifferentiated and proliferative developmental states.
miR-592 expression is also altered in hepatocellular carcinoma; it has been shown to be downregulated along with nine other microRNAs.
See also
Further reading
- Wang . W. . Zhao . L. -J. . Tan . Y. -X. . Ren . H. . Qi . Z. -T. . MiR-138 induces cell cycle arrest by targeting cyclin D3 in hepatocellular carcinoma . 10.1093/carcin/bgs113 . Carcinogenesis . 33 . 5 . 1113–1120 . 2012 . 22362728 . 3334515 .
Notes and References
- Sarver AL, French AJ, Borralho PM, Thayanithy V, Oberg AL, Silverstein KA, etal . Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states. . BMC Cancer . 2009 . 9 . 401 . 19922656 . 10.1186/1471-2407-9-401 . 2787532 . free .
- Oberg AL, French AJ, Sarver AL, Subramanian S, Morlan BW, Riska SM, etal . miRNA expression in colon polyps provides evidence for a multihit model of colon cancer. . PLOS ONE . 2011 . 6 . 6 . e20465 . 21694772 . 10.1371/journal.pone.0020465 . 3111419 . 2011PLoSO...620465O . free .
