Mir-590 microRNA precursor family explained

mir-590
Symbol:	mir-590
Rfam:	RF00928
Mirbase Family:	MIPF0000418
Rna Type:	microRNA
Tax Domain:	Eukaryota

In molecular biology mir-590 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Nicotine-induced atrial remodelling

Downregulation of miR-590 by nicotine has been found to play a key part in the generation of atrial fibrosis by atrial structural remodelling. This downregulation sees the removal of post-transcriptional repression of TGF-β1 and TGF-β receptor type II (TGF-βRII), and consequent collagen production.^[1] miR-590 downregulation has further been shown to be mediated by activation of alpha-7 nicotinic acetylcholine receptors (α7-nAChRs).

See also

• MicroRNA

Further reading

• Monteys AM, Spengler RM, Wan J, Tecedor L, Lennox KA, Xing Y, Davidson BL . Structure and activity of putative intronic miRNA promoters . RNA . 16 . 3 . 495–505 . March 2010 . 20075166 . 2822915 . 10.1261/rna.1731910 .

Notes and References

1. Shan H, Zhang Y, Lu Y, Zhang Y, Pan Z, Cai B, Wang N, Li X, Feng T, Hong Y, Yang B . Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines . Cardiovascular Research . 83 . 3 . 465–72 . August 2009 . 19398468 . 10.1093/cvr/cvp130 . free .