Mir-46/mir-47/mir-281 microRNA precursor family explained

mir-46/mir-47/mir-281 microRNA precursor family
Symbol:	mir-46
Rfam:	RF00249
Mirbase:	MI0000017
Mirbase Family:	MIPF0000087
Rna Type:	Gene miRNA
Tax Domain:	Eukaryota

In molecular biology, mir-46 (MI0000017) and mir-47 (MI0000018) are microRNA expressed in C. elegans from related hairpin precursor sequences.^[1] The predicted hairpin precursor sequences for Drosophila mir-281 (MI0000366, MI0000370)^{[2] [3]} are also related and, hence, belong to this family. The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequences are expressed from the 3' arms of the hairpin precursors.

External links

• • MI0000017
• MI0000018
• MI0000366
• MI0000370

Notes and References

1. Lau NC, Lim LP, Weinstein EG, Bartel DP . An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans . Science . 294 . 5543 . 858–62 . October 2001 . 11679671 . 10.1126/science.1065062 . 43262684 .
2. Lai EC, Tomancak P, Williams RW, Rubin GM . Computational identification of Drosophila microRNA genes . Genome Biology . 4 . 7 . R42 . 2003 . 12844358 . 193629 . 10.1186/gb-2003-4-7-r42 . free .
3. Aravin AA, Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T . The small RNA profile during Drosophila melanogaster development . Developmental Cell . 5 . 2 . 337–50 . August 2003 . 12919683 . 10.1016/S1534-5807(03)00228-4 . 11858/00-001M-0000-0010-94E8-6 . free .