Mir-451 microRNA explained

mir-451
Width:	220px
Symbol:	mir-451
Rfam:	RF00722
Mirbase Family:	MIPF0000148
Rna Type:	microRNA
Tax Domain:	Eukaryota Vertebrata
Omim:	612071

In molecular biology mir-451 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-451 regulates the drug-transporter protein P-glycoprotein, potentially promoting resistance to the chemotherapy drug Paclitaxel.^[1]

Applications

A proof-of-concept experiment has shown that miR-451, as well as mir-126 and mir-150, could be using in forensic science to distinguish between blood and saliva samples.^[2] This is made possible by different miRNA profiles of miRNAs in the different tissue types.

Further reading

• Yang JS, Maurin T, Robine N, Rasmussen KD, Jeffrey KL, Chandwani R, Papapetrou EP, Sadelain M, O'Carroll D, Lai EC . Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. . Proc Natl Acad Sci U S A . 107 . 34 . 15163–15168 . 2010 . 20699384 . 10.1073/pnas.1006432107 . 2930549. 2010PNAS..10715163Y . free .
• Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D'Souza J, Zhang Z, Ghaffari S, Choi J, Friend S, Tong W, Orange JS, Paw BH, Weiss MJ . miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. . Genes Dev . 24 . 15 . 1620–1633 . 2010 . 20679398 . 10.1101/gad.1942110 . 2912560.
• Patrick DM, Zhang CC, Tao Y, Yao H, Qi X, Schwartz RJ, Jun-Shen Huang L, Olson EN . Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta. . Genes Dev . 24 . 15 . 1614–1619 . 2010 . 20679397 . 10.1101/gad.1942810 . 2912559.
• Godlewski J, Bronisz A, Nowicki MO, Chiocca EA, Lawler S . microRNA-451: A conditional switch controlling glioma cell proliferation and migration. . Cell Cycle . 9 . 14 . 2742–2748 . 2010 . 20647762. 10.4161/cc.9.14.12248 . free .
• Svasti S, Masaki S, Penglong T, Abe Y, Winichagoon P, Fucharoen S, Umemura T . Expression of microRNA-451 in normal and thalassemic erythropoiesis. . Ann Hematol . 89 . 10 . 953–958 . 2010 . 20461517 . 10.1007/s00277-010-0980-7. 35296680 .
• Godlewski J, Nowicki MO, Bronisz A, Nuovo G, Palatini J, De Lay M, Van Brocklyn J, Ostrowski MC, Chiocca EA, Lawler SE . MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. . Mol Cell . 37 . 5 . 620–632 . 2010 . 20227367 . 10.1016/j.molcel.2010.02.018 . 3125113.
• Bruchova-Votavova H, Yoon D, Prchal JT . miR-451 enhances erythroid differentiation in K562 cells. . Leuk Lymphoma . 51 . 4 . 686–693 . 2010 . 20218812 . 10.3109/10428191003629362. 36579523 .
• Tsuchiya S, Oku M, Imanaka Y, Kunimoto R, Okuno Y, Terasawa K, Sato F, Tsujimoto G, Shimizu K . MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells. . Nucleic Acids Res . 37 . 11 . 3821–3827 . 2009 . 19386621 . 10.1093/nar/gkp255 . 2699527.
• Bandres E, Bitarte N, Arias F, Agorreta J, Fortes P, Agirre X, Zarate R, Diaz-Gonzalez JA, Ramirez N, Sola JJ, Jimenez P, Rodriguez J, Garcia-Foncillas J . microRNA-451 regulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells. . Clin Cancer Res . 15 . 7 . 2281–2290 . 2009 . 19318487 . 10.1158/1078-0432.CCR-08-1818. free .
• Pase L, Layton JE, Kloosterman WP, Carradice D, Waterhouse PM, Lieschke GJ . miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2. . Blood . 113 . 8 . 1794–1804 . 2009 . 18849488 . 10.1182/blood-2008-05-155812 . 2647672.
• Gal H, Pandi G, Kanner AA, Ram Z, Lithwick-Yanai G, Amariglio N, Rechavi G, Givol D . MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells. . Biochem Biophys Res Commun . 376 . 1 . 86–90 . 2008 . 18765229 . 10.1016/j.bbrc.2008.08.107.
• Kovalchuk O, Filkowski J, Meservy J, Ilnytskyy Y, Tryndyak VP, Chekhun VF, Pogribny IP . Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. . Mol Cancer Ther . 7 . 7 . 2152–2159 . 2008 . 18645025 . 10.1158/1535-7163.MCT-08-0021. free .
• Zhu H, Wu H, Liu X, Evans BR, Medina DJ, Liu CG, Yang JM . Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. . Biochem Pharmacol . 76 . 5 . 582–588 . 2008 . 18619946 . 10.1016/j.bcp.2008.06.007 . 2628586.

External links

• • Web site: MicroRNA MIR451 family (MIR451) Gene group . HUGO Gene Nomenclature Committee (HGNC) .

Notes and References

1. van Jaarsveld. MT. Helleman, J . Berns, EM . Wiemer, EA . MicroRNAs in ovarian cancer biology and therapy resistance.. The International Journal of Biochemistry & Cell Biology. August 2010. 42. 8. 1282–1290. 20083225. 10.1016/j.biocel.2010.01.014.
2. Courts. C. Madea, B. Specific Micro-RNA Signatures for the Detection of Saliva and Blood in Forensic Body-fluid Identification.. Journal of Forensic Sciences. Aug 9, 2011. 21827476. 10.1111/j.1556-4029.2011.01894.x. 56. 6. 1464–1470. 41948164.