Mir-192/215 microRNA precursor explained

mir-192/215 microRNA precursor
Symbol:mir-192
Rfam:RF00130
Mirbase:MI0000234
Mirbase Family:MIPF0000063
Rna Type:Gene
miRNA
Tax Domain:Eukaryota

The miR-192 microRNA precursor (homologous to miR-215), is a short non-coding RNAgene involved in gene regulation.miR-192 and miR-215 have now been predicted or experimentally confirmed in mouse and human.[1] [2]

microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to haveregulatory roles through complementarity to mRNA.[3]

mir-192 and mir-215 are thought to be positive regulators of p53, a human tumour suppressor.[4] They are also overexpressed in gastric cancer, and could be used as biomarkers or therapeutic targets.[5] It has also been suggested that mir-192 could be used as a biomarker for drug-induced liver damage.[6]

miR-215 and miR-192 are also both implicated in major depressive disorder. Small-RNA sequencing reveals upregulated expression for both miR-215 and miR-192 in the synaptosomes derived from the dorsolateral prefrontal cortex of MDD subjects.[7]

External links

Notes and References

  1. Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T . New microRNAs from mouse and human . RNA . 9 . 2 . 175–9 . Feb 2003 . 12554859 . 1370382 . 10.1261/rna.2146903 .
  2. Web site: miRNA gene family: mir-192. https://web.archive.org/web/20070929092748/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000063. dead. September 29, 2007. mirBASE. University of Manchester.
  3. Ambros V . microRNAs: tiny regulators with great potential . Cell . 107 . 7 . 823–6 . Dec 2001 . 11779458 . 10.1016/S0092-8674(01)00616-X . free .
  4. Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, Santhanam R, Zhou W, Benson DM, Hofmainster C, Alder H, Garofalo M, Di Leva G, Volinia S, Lin HJ, Perrotti D, Kuehl M, Aqeilan RI, Palumbo A, Croce CM . Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development . Cancer Cell . 18 . 4 . 367–81 . Oct 2010 . 20951946 . 3561766 . 10.1016/j.ccr.2010.09.005 .
  5. Jin Z, Selaru FM, Cheng Y, Kan T, Agarwal R, Mori Y, Olaru AV, Yang J, David S, Hamilton JP, Abraham JM, Harmon J, Duncan M, Montgomery EA, Meltzer SJ . MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro . Oncogene . 30 . 13 . 1577–85 . Mar 2011 . 21119604 . 10.1038/onc.2010.534 . 4586057 .
  6. Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, Hood LE, Galas DJ . Circulating microRNAs, potential biomarkers for drug-induced liver injury . Proceedings of the National Academy of Sciences of the United States of America . 106 . 11 . 4402–7 . Mar 2009 . 19246379 . 2657429 . 10.1073/pnas.0813371106 . free .
  7. Yoshino Y, Roy B, Dwivedi Y . Differential and unique patterns of synaptic miRNA expression in dorsolateral prefrontal cortex of depressed subjects. . Neuropsychopharmacology . 46 . 5 . 900–910 . Apr 2021 . 32919404 . 8115313 . 10.1038/s41386-020-00861-y . free .

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