Mir-187 microRNA precursor family explained

mir-187
Symbol:mir-187
Rfam:RF00674
Mirbase Family:8
Rna Type:microRNA
Tax Domain:Eukaryota

In molecular biology mir-187 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-187 has been found to be expressed at higher levels in ovarian cancers compared with benign tumours.[1] It is known to target DAB2 (disabled homolog-2), a protein encoded by the DAB2 gene, with miR-187's target site at the 3'UTR of the DAB2 gene. DAB2 has been seen to play roles in both cell proliferation and tumour progression, and initial expression of miR-187 in cancer cells promotes cell proliferation. However, overexpression suppresses DAB2 and inhibits epithelial to mesenchymal cell transition. High miR-187 levels have accordingly been associated with higher survival rates in ovarian cancer patients.[1]

See also

Further reading

[2] [3] [4] [5] [6] [7] [8]

Notes and References

  1. Chao A, Lin CY, Lee YS, Tsai CL, Wei PC, Hsueh S, etal . Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2. . Oncogene . 2012 . 31 . 6 . 764–75 . 21725366 . 10.1038/onc.2011.269 .
  2. Shaoqing . Y. . Ruxin . Z. . Guojun . L. . Zhiqiang . Y. . Hua . H. . Shudong . Y. . Jie . Z. . 10.2500/ajra.2011.25.3682 . Microarray analysis of differentially expressed microRNAs in allergic rhinitis . American Journal of Rhinology and Allergy . 25 . 6 . e242–e246 . 2011 . 22185732 . 45915750 .
  3. Liu . H. . Zhu . L. . Liu . B. . Yang . L. . Meng . X. . Zhang . W. . Ma . Y. . Xiao . H. . 10.1016/j.canlet.2011.10.034 . Genome-wide microRNA profiles identify miR-378 as a serum biomarker for early detection of gastric cancer . Cancer Letters . 316 . 2 . 196–203 . 2012 . 22169097 .
  4. Godwin . J. G. . Ge . X. . Stephan . K. . Jurisch . A. . Tullius . S. G. . Iacomini . J. . 10.1073/pnas.0912701107 . Identification of a microRNA signature of renal ischemia reperfusion injury . Proceedings of the National Academy of Sciences . 107 . 32 . 14339–14344 . 2010 . 20651252 . 2922548 . 2010PNAS..10714339G . free .
  5. Nicoloso . M. S. . Sun . H. . Spizzo . R. . Kim . H. . Wickramasinghe . P. . Shimizu . M. . Wojcik . S. E. . Ferdin . J. . Kunej . T. . Xiao . 10.1158/0008-5472.CAN-09-3541 . L. . Manoukian . S. . Secreto . G. . Ravagnani . F. . Wang . X. . Radice . P. . Croce . C. M. . Davuluri . R. V. . Calin . G. A. . Single-Nucleotide Polymorphisms Inside MicroRNA Target Sites Influence Tumor Susceptibility . Cancer Research . 70 . 7 . 2789–2798 . 2010 . 20332227 . 2853025 .
  6. Xu . G. . Zhang . Y. . Jia . H. . Li . J. . Liu . X. . Engelhardt . J. F. . Wang . Y. . 10.1007/s11010-009-0168-4 . Cloning and identification of microRNAs in bovine alveolar macrophages . Molecular and Cellular Biochemistry . 332 . 1–2 . 9–16 . 2009 . 19507003 . 10508574 .
  7. Palmieri . A. . Pezzetti . F. . Avantaggiato . A. . Lo Muzio . L. L. . Scarano . A. . Rubini . C. . Guerzoni . L. . Arlotti . M. . Ventorre . D. . 10.1563/0.869.1 . Carinci . F. . Titanium Acts on Osteoblast Translational Process . Journal of Oral Implantology . 34 . 4 . 190–195 . 2008 . 18780563 .
  8. Nikiforova . M. N. . Tseng . G. C. . Steward . D. . Diorio . D. . Nikiforov . Y. E. . MicroRNA Expression Profiling of Thyroid Tumors: Biological Significance and Diagnostic Utility . 10.1210/jc.2007-2696 . Journal of Clinical Endocrinology & Metabolism . 93 . 5 . 1600–1608 . 2008 . 18270258 . 2386678 .

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