Mir-160 microRNA precursor family explained
| mir-160 microRNA precursor family |
| Symbol: | mir-160 |
| Rfam: | RF00247 |
| Mirbase: | MI0000190 |
| Mirbase Family: | MIPF0000032 |
| Rna Type: | Gene
- miRNA
|
| Tax Domain: | Eukaryota |
In molecular biology, mir-160 is a microRNA that has been predicted or experimentally confirmed in a range of plant species including Arabidopsis thaliana (mouse-ear cress) and Oryza sativa (rice).[1] miR-160 is predicted to bind complementary sites in the untranslated regions of auxin response factor genes to regulate their expression.[2] The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequence is excised from the 5' arm of the hairpin.
Specifically, 3 of A. thalianas 23 auxin-response factor genes are thought to be post-transcriptionally regulated by mir-160.[3] [4] When one of these targets (ARF17) is manipulated to become miRNA-resistant, several developmental defects can be observed in the host plant. This experiment has been repeated with another mir-160 target, ARF10, and results highlighted a regulatory role in post-embryonic development and seed germination.[5]
External links
Notes and References
- Web site: miRNA gene family: MIR160. mirBASE. University of Manchester. 5 September 2011. dead. https://archive.today/20120715025643/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000032. 15 July 2012.
- Rhoades MW, Reinhart BJ, Lim LP, Burge CB, Bartel B, Bartel DP . Prediction of plant microRNA targets . Cell . 110 . 4 . 513–20 . August 2002 . 12202040 . 10.1016/S0092-8674(02)00863-2 . free .
- Mallory AC, Bartel DP, Bartel B . MicroRNA-directed regulation of Arabidopsis AUXIN RESPONSE FACTOR17 is essential for proper development and modulates expression of early auxin response genes . The Plant Cell . 17 . 5 . 1360–75 . May 2005 . 15829600 . 1091760 . 10.1105/tpc.105.031716 .
- Liu X, Huang J, Wang Y, Khanna K, Xie Z, Owen HA, Zhao D . The role of floral organs in carpels, an Arabidopsis loss-of-function mutation in MicroRNA160a, in organogenesis and the mechanism regulating its expression . The Plant Journal . 62 . 3 . 416–28 . May 2010 . 20136729 . 10.1111/j.1365-313X.2010.04164.x . free .
- Liu PP, Montgomery TA, Fahlgren N, Kasschau KD, Nonogaki H, Carrington JC . Repression of AUXIN RESPONSE FACTOR10 by microRNA160 is critical for seed germination and post-germination stages . The Plant Journal . 52 . 1 . 133–46 . October 2007 . 17672844 . 10.1111/j.1365-313X.2007.03218.x . free .
