Mir-103/107 microRNA precursor explained
| mir-103/107 microRNA precursor |
| Symbol: | mir-103 |
| Rfam: | RF00129 |
| Mirbase: | MI0000109 |
| Mirbase Family: | MIPF0000024 |
| Rna Type: | Gene
- miRNA
|
| Tax Domain: | Eukaryota |
The miR-103 microRNA precursor (homologous to miR-107), is a short non-coding RNA gene involved in gene regulation.miR-103 and miR-107 have now been predicted or experimentally confirmed in human.[1] [2]
microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes fromthe 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.[3]
mir-103 and mir-107 were noted as being upregulated in obese mice and were subsequently found to have a key role in insulin sensitivity. This led to a suggestion that these microRNAs represent potential targets for the treatment of type 2 diabetes.[4]
mir-103 has also been linked with chronic pain[5] and intestinal cell proliferation.[6]
Recently, miR-103-3p was shown to target the 5' untranslated region (5' UTR) of GPRC5A's mRNA in pancreatic cancer.[7] This is one of only a handful of known instances where a miRNA targets the 5' UTR of a mRNA.
External links
Notes and References
- Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G . miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs . Genes & Development . 16 . 6 . 720–8 . March 2002 . 11914277 . 155365 . 10.1101/gad.974702 .
- Web site: miRNA gene family: mir-103. mirBASE. University of Manchester. 5 September 2011. dead. https://archive.today/20120710015407/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000024. 10 July 2012.
- Ambros V . microRNAs: tiny regulators with great potential . Cell . 107 . 7 . 823–6 . December 2001 . 11779458 . 10.1016/S0092-8674(01)00616-X . free .
- Trajkovski M, Hausser J, Soutschek J, Bhat B, Akin A, Zavolan M, Heim MH, Stoffel M . MicroRNAs 103 and 107 regulate insulin sensitivity . Nature . 474 . 7353 . 649–53 . June 2011 . 21654750 . 10.1038/nature10112 . 2060531 .
- Favereaux A, Thoumine O, Bouali-Benazzouz R, Roques V, Papon MA, Salam SA, Drutel G, Léger C, Calas A, Nagy F, Landry M . Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain . The EMBO Journal . 30 . 18 . 3830–41 . July 2011 . 21804529 . 3173784 . 10.1038/emboj.2011.249 .
- Liao Y, Lönnerdal B . Global microRNA characterization reveals that miR-103 is involved in IGF-1 stimulated mouse intestinal cell proliferation . PLOS ONE . 5 . 9 . e12976 . September 2010 . 20886090 . 2944884 . 10.1371/journal.pone.0012976 . Langsley . Gordon . free .
- Zhou H, Rigoutsos I . MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells . RNA . 20 . 9 . 1431–9 . September 2014 . 24984703 . 4138326 . 10.1261/rna.045757.114 .
