Mipafox Explained

Mipafox is a highly toxic organophosphate insecticide that is an irreversible acetylcholinesterase inhibitor and is resistant to cholinesterase reactivators.^[1] It was developed in the 1950s and is now believed to be no longer in use.^[2]

Toxicity

There are case reports of delayed neurotoxicity and paralysis due to acute exposure to mipafox.^[3]

Synthesis

Phosphoryl chloride is first reacted with isopropylamine. The resulting product is then reacted with potassium fluoride or ammonium fluoride to produce mipafox.^[4]

See also

• Dimefox
• Schradan

Notes and References

1. Mangas . I . Taylor . P . Vilanova . E . Estévez . J . França . TC . Komives . E . Radić . Z . Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches. . Archives of Toxicology . March 2016 . 90 . 3 . 603–16 . 10.1007/s00204-015-1481-1 . 25743373 . 4833118.
2. Web site: The WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 2019. World Health Organization .
3. BIDSTRUP . PL . BONNELL . JA . BECKETT . AG . Paralysis following poisoning by a new organic phosphorus insecticide (mipafox); report on two cases. . British Medical Journal . 16 May 1953 . 1 . 4819 . 1068–72 . 13042137 . 2016450 . 10.1136/bmj.1.4819.1068.
4. Web site: Process for the preparation of bisisopropyl-amino-fluoro-phosphine oxide .