Miotine Explained

Miotine is an anticholinesterase drug. Miotine was the first synthetic carbamate that was used clinically.^[1]

Unlike the miotine analog neostigmine, it doesn't have a quaternary ammonium group to give it a permanent positive charge. It can exist as an uncharged free base which could allow it to cross the blood–brain barrier and cause unwanted central nervous system (CNS) side effects.^[2]

See also

• Neostigmine
• T-1123
• TL-1238
• TMTFA

References

1. Web site: Archived copy . 2008-01-04 . https://web.archive.org/web/20090509211158/http://www.weizmann.ac.il/sb/faculty_pages/Sussman/papers/2002_Bar-On_Biochem.pdf . 2009-05-09 . dead .
2. Web site: An introduction to drugs,their action and discovery.