The Minister for Foreign Affairs is the Ghana government official who is responsible for overseeing the country's foreign policy and international diplomacy. The foreign minister is usually one of the most senior members of Cabinet. Under military regimes in Ghana, the title; minister has been replaced with commissioner or secretary.
The Minister for Foreign Affairs since January 2017 has been Honorable Shirley Ayorkor Botchway. The ministry is at present combined with other portfolios to form the Ministry of Foreign Affairs and Regional Integration under the government of Nana Akufo-Addo of the New Patriotic Party.
| Number | width=200 | Minister | Took office | Left office | width=200 | Government | width=200 | Party |
|---|---|---|---|---|---|---|---|---|
| 1 | Ako Adjei (MP) | 1961 | 1962 | Convention Peoples' Party | ||||
| 2 | 1962 | 1963 | ||||||
| 3 | Kojo Botsio (MP) | 1963 | 1965 | |||||
| 4 | 1965 | 24 February 1966 | ||||||
| 5 | 1966 | 1967 | Military government | |||||
| 6 | 1967 | 1968 | ||||||
| 7 | Patrick Dankwa Anin (MP) | 1969 | 1969 | Progress Party | ||||
| 8 | Victor Owusu (MP) | 1969 | 1969 | |||||
| 9 | Patrick Dankwa Anin (MP) | 1969 | 1969 | |||||
| 10 | Victor Owusu (MP) | 1969 | 1971 | |||||
| 11 | William Ofori Atta (MP) | 1971 | 13 January 1972 | |||||
| 12 | 1972 | 1972 | Military government | |||||
| 13 | 1972 | 1975 | ||||||
| 14 | 1975 | 4 June 1979 | Supreme Military Council | |||||
| 15 | Mrs. Gloria Amon Nikoi[2] | 1979 | 24 September 1979 | |||||
| 16 | 1979 | 31 December 1981 | Peoples National Party | |||||
| 17 | 1982 | 7 January 1993 | Military government | |||||
| 18 | 7 January 1993 | 1997 | ||||||
| 19 | Kwamena Ahwoi (acting) | 1997 | 1997 | |||||
| 20 | 1997 | 7 January 2001 | ||||||
| 21 | Hackman Owusu-Agyeman (MP) | 2001 | 2003 | New Patriotic Party | ||||
| 22 | Nana Addo Dankwa Akufo-Addo (MP) | 2003 | July 2007 | |||||
| 23 | Akwasi Osei-Adjei (MP)[3] | 2007 | 7 January 2009 | |||||
| 24 | 2009 | 24 July 2012 | ||||||
| 24 July 2012 | 7 January 2013 | Mahama government | ||||||
| 25 | Hanna Tetteh (MP)[4] | 30 January 2013 | 6 January 2017 | |||||
| 26 | Shirley Ayorkor Botchway (MP)[5] | 28 January 2017 | Incumbent | New Patriotic Party |