| Agency Name: | Ministry of Science, Technology and Innovation |
| Type: | Ministry |
| Nativename: | Kementerian Sains, Teknologi dan Inovasi |
| Native Name A: | MOSTI |
| Seal: | Coat of arms of Malaysia.svg |
| Jurisdiction: | Government of Malaysia |
| Formed: | 1973 |
| Preceding1: | Ministry of Energy, Science, Technology, Environment and Climate Change (MESTECC) |
| Headquarters: | Level 1-7, Block C4 & C5, Complex C, Federal Government Administration, 62662, Putrajaya, Malaysia. |
| Region Code: | MY |
| Minister1 Name: | Chang Lih Kang |
| Minister1 Pfo: | Minister of Science, Technology and Innovation |
| Deputyminister1 Name: | Yusof Apdal |
| Deputyminister1 Pfo: | Deputy Minister of Science, Technology and Innovation |
| Chief1 Name: | Datuk Zainal Abidin Abu Hassan |
| Chief1 Position: | Secretary-General |
The Ministry of Science, Technology and Innovation (Malay: '''Kementerian Sains, Teknologi dan Innovatif'''), abbreviated MOSTI, is a ministry of the Government of Malaysia.
In the Seventh Mahathir cabinet, the entire component of the Ministry of Science, Technology and Innovation (MOSTI), Green Technology and Energy Components from the Ministry of Energy, Green Technology and Water (KeTTHA) and related components of Climate Change and Environment from the Ministry of Natural resources and Environment (NRE) has been restructured and formed the Ministry of Energy, Science, Technology, Environment & Climate Change (MESTECC). After the 2020 Malaysian political crisis, MESTECC has been restructured and its name has been changed to the Ministry of Science, Technology and Innovation (MOSTI) following the formation of the Muhyiddin cabinet.[1] In the Anwar Ibrahim cabinet, the ministry was renamed to Ministry of Science and Technology with the removal of the innovation portfolio from the name.
The current Minister of Science, Technology and Innovation has been Chang Lih Kang since 3 December 2022.