The Ministries of Djibouti are headed by the Cabinet. It runs the day-to-day operations of the Government of Djibouti. The Council of Ministers is in turn appointed by the President, the actual head of government, on the proposal of the Prime Minister, who serves as its most senior minister.
| Ministry | Title of Minister | Incumbent | |
|---|---|---|---|
| Ministry of Agriculture, Livestock, & Fisheries | Minister of Agriculture, Livestock, & Fisheries | Mohamed Ahmed AWALEH | |
| Ministry of Communication & Culture | Minister of Communication & Culture | Ali Hassan BAHDON | |
| Ministry of Defense | Minister of Defense | Hassan Darar HOUFFANEH | |
| Ministry of Economy, Finance, & Planning | Minister of Economy, Finance, & Planning | Ilyas Moussa Dawaleh | |
| Ministry of Education & Professional Training | Minister of Education & Professional Training | Djama Elmi OKIEH | |
| Ministry of Energy & Water | Minister of Energy & Water | Ali YACOUB | |
| Ministry of Foreign Affairs & Intl. Cooperation | Minister of Foreign Affairs & Intl. Cooperation | Mahamoud Ali YOUSSOUF | |
| Ministry of Habitat, Urban Planning, Environment, & Town Planning | Minister of Habitat, Urban Planning, Environment, & Town Planning | Mohamed Moussa Ibrahim BALALA | |
| Ministry of Health | Minister of Health | Kassim Issack OSMAN | |
| Ministry of Infrastructure & Transport | Minister of Infrastructure & Transport | Moussa Ahmed HASSAN | |
| Ministry of Interior | Minister of Interior | Hassan Omar Mohamed BOURHAN | |
| Ministry of Justice & Penal Affairs | Minister of Justice & Penal Affairs | Ali Farah Assoweh | |
| Ministry of Labor | Minister of Labor | Adbi Houssein AHMED | |
| Ministry of Muslim Affairs & Charitable Assets | Minister of Muslim Affairs & Charitable Assets | Aden Ali ADEN | |
| Ministry of the Promotion of Women & Family Welfare & Social Affairs | Minister of the Promotion of Women & Family Welfare & Social Affairs | Hasna Barkat DAOUD |