| Agency Name: | Ministry of Defence of the Czech Republic |
| Nativename: | Czech: Ministerstvo obrany České republiky |
| Picture Width: | 250px |
| Picture Caption: | Ministry of Defence building in Prague |
| Formed: | 8 December 1992 |
| Preceding1: | Czechoslovak Ministry of National Defence |
| Jurisdiction: | Government of the Czech Republic |
| Headquarters: | Tychonova 1, 160 01 Prague 6 |
| Chief1 Name: | Jana Černochová |
| Chief1 Position: | Minister |
| Child1 Agency: | Military Intelligence |
| Child2 Agency: | University of Defence |
| Website: | mocr.army.cz |
The Ministry of Defence of the Czech Republic (Czech: Ministerstvo obrany České republiky, MO ČR) is the primary agency of the Czech Republic responsible for the planning and carrying-out of defense policy. It is the Czech Republic's ministry of defence. It is the direct successor of the Czechoslovak Ministry of Defence. Its current headquarters is located in Prague. The current Minister of Defence is Jana Černochová, in office since 17 December 2021.