| Official Name: | Milo Center, Texas |
| Settlement Type: | Unincorporated community |
| Pushpin Map: | Texas#USA |
| Pushpin Label: | Milo Center |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Texas |
| Subdivision Type2: | County |
| Subdivision Name2: | Deaf Smith |
| Timezone: | Central (CST) |
| Utc Offset: | -6 |
| Timezone Dst: | CDT |
| Utc Offset Dst: | -5 |
| Elevation Ft: | 3,914 |
| Coordinates: | 34.9831°N -102.4022°W |
| Area Code: | 806 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 1380199 |
Milo Center is an unincorporated community in Deaf Smith County, in the U.S. state of Texas. According to the Handbook of Texas, the community had a population of 5 in 2000.
Milo Center is located on U.S. Route 385, north of Hereford in east-central Deaf Smith County.
Milo Center joined the Hereford Independent School District in 1939. Today, the community is zoned for Bluebonnet Elementary School.