| Official Name: | Millersville, Missouri |
| Settlement Type: | Census-Designated Place |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Missouri |
| Subdivision Type2: | County |
| Subdivision Name2: | Cape Girardeau |
| Leader Title: | Mayor |
| Leader Name: | Kelton S. Horrell |
| Leader Title1: | Mayor |
| Unit Pref: | Imperial |
| Area Footnotes: | [1] |
| Area Total Km2: | 2.93 |
| Area Land Km2: | 2.93 |
| Area Water Km2: | 0.00 |
| Area Total Sq Mi: | 1.13 |
| Area Land Sq Mi: | 1.13 |
| Area Water Sq Mi: | 0.00 |
| Population As Of: | 2020 |
| Population Total: | 240 |
| Population Density Km2: | 81.79 |
| Population Density Sq Mi: | 211.83 |
| Postal Code Type: | ZIP code |
| Postal Code: | 63766[2] |
| Area Code: | 573 |
| Blank Name: | FIPS code |
| Blank Info: | 29-48350 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 722401 |
Millersville is an unincorporated community in western Cape Girardeau County, Missouri, United States. It is located six miles (10 km) west of Jackson on Route 72.
Millersville is part of the Cape Girardeau - Jackson, MO-IL Metropolitan Statistical Area.
A post office called Millersville has been in operation since 1866.[3]
The community was named after the local Miller family.[4]
The Miller-Seabaugh House and Dr. Seabaugh Office Building was listed on the National Register of Historic Places in 1996.
It is in the Jackson R-2 School District,[5] which operates Jackson High School.