| Milica Despina of Serbia | |
| Succession: | Regent of Wallachia |
| Reign: | 1521–1522 |
| Reign-Type: | Regency |
| Regent: | Teodosie of Wallachia |
| Reg-Type: | Voivode |
| Succession1: | Princess Consort of Wallachia |
| Reign1: | 1512–1521 |
| Reign-Type1: | Tenure |
| Father: | Jovan Branković, Despot of Serbia or Đorđe Branković, Despot of Serbia |
| Mother: | Jelena Jakšić or Isabella del Balzo |
| Spouse: | Neagoe Basarab of Wallachia |
| Issue: | Teodosie of Wallachia Ioan Petru Stana of Wallachia Angelina of Wallachia Ruxandra of Wallachia |
| Birth Date: | c.1485 |
| Death Date: | 30 January 1554 |
| Death Place: | Sibiu, Transylvania |
| House: | House of Branković (by birth) House of Craiovești (by marriage) |
Milica Despina (Serbian: Милица Деспина; ro|Milița Despina; – 30 January 1554) was the Princess consort of Wallachia by marriage to Neagoe Basarab . She was regent of Wallachia from 1521 to 1522, on the behalf of her son Teodosie of Wallachia. In later years, she became a nun, and took the name Platonida.
Princess Milica Despina was of Serbian origin, and closely related to noble houses of Branković and Lazarević. In historiography, there are several theories about her parents. Some scholars think that she was one of the daughters of Serbian despot Jovan Branković who died in 1502.[1] Others think that she was daughter of Jovan's elder brother, Serbian despot Đorđe Branković who died in 1516. There is also some other views about her origin.[2]
Milica Despina and Neagoe Basarab had six children: