| Milena Mesa | |
| Nationality: | Cuban |
| Birth Date: | 26 June 1993 |
| Position: | Right back |
| Currentclub: | Holguín |
| Nationalteam1: | Cuba |
| Nationalcaps1: | 29 |
| Nationalgoals1: | 40 |
Milena Mesa Matos (born 26 June 1993) is a Cuban handball player. She plays on the Cuba women's national handball team and participated at the 2011 World Women's Handball Championship in Brazil.[1]