Benign lymphoepithelial lesion explained

Benign lymphoepithelial lesion
Synonyms:	Mikulicz' disease

Benign lymphoepithelial lesion or Mikulicz' disease is a type of benign enlargement of the parotid and/or lacrimal glands. This pathologic state is sometimes, but not always, associated with Sjögren's syndrome.

Eponym

Historically, bilateral parotid and lacrimal gland enlargement was characterized by the term Mikulicz's disease if the enlargement appeared apart from other diseases. If it was secondary to another disease, such as tuberculosis, sarcoidosis, lymphoma, and Sjögren's syndrome, the term used was Mikulicz's syndrome. Both names derive from Jan Mikulicz-Radecki, the Polish surgeon best known for describing these conditions.^{[1] [2]}

In more recent times, the terms "Mikulicz's disease" and "Mikulicz's syndrome" were viewed as ambiguous and outdated by some sources.^[3]

Today Mikulicz's disease is considered to be a subtype of IgG4-related disease, usually accompanied by involvement of one or more other organs in the body.^[4]

See also

• Lymphoepithelial lesion

Further reading

• Kahn. LB. Benign lymphoepithelial lesion (Mikulicz's disease) of the salivary gland: an ultrastructural study.. Human Pathology. Jan 1979. 10. 1. 99–104. 428999. 10.1016/S0046-8177(79)80077-5.
• Lee S, Tsirbas A, McCann J, Goldberg R . Mikulicz's disease: a new perspective and literature review. . Eur J Ophthalmol . 16 . 2 . 199–203 . 2006 . 10.1177/112067210601600201 . 16703534. 24906450 .
• Tsubota. K. Fujita. H. Tsuzaka. K. Takeuchi. T. Mikulicz's disease and Sjögren's syndrome.. Investigative Ophthalmology & Visual Science. Jun 2000. 41. 7. 1666–73. 10845583.
• Azzopardi. JG. Evans. DJ. Malignant lymphoma of parotid associated with Mikulicz disease (benign lymphoepithelial lesion). J Clin Pathol. Nov 1971. 24. 8. 744–752. 477147. 4943296. 10.1136/jcp.24.8.744.
• Yamamoto. M. Harada. S. Ohara. M. Suzuki. C. Naishiro. Y. Yamamoto. H. Takahashi. H. Imai. K. Clinical and pathological differences between Mikulicz's disease and Sjögren's syndrome.. Rheumatology. Feb 2005. 44. 2. 227–34. 10.1093/rheumatology/keh447. 15509627. free.
• Delaney. William E.. Balogh. Károly. Carcinoma of the parotid gland associated with benign lymphoepithelial lesion (Mikulicz's disease) in Sjögren's syndrome. Cancer. 19. 6. 853–860. 10.1002/1097-0142(196606)19:6<853::AID-CNCR2820190617>3.0.CO;2-N. 1966. 5939056.

External links

• Mikulicz syndrome on The National Organization for Rare Disorders (NORD)
• Benign lymphoepithelial lesions on Radiopedia

Notes and References

1. - "Mikulicz's disease"
2. - "Mikulicz's syndrome"
3. Ihrler S, Harrison J . Mikulicz's disease and Mikulicz's syndrome: analysis of the original case report of 1892 in the light of current knowledge identifies a MALT lymphoma. . Oral Surg Oral Med Oral Pathol Oral Radiol Endod . 100 . 3 . 334–9 . 2005 . 16122662 . 10.1016/j.tripleo.2005.01.016. MALT lymphoma .
4. John H. Stone . Arezou Khosroshahi . Vikram Deshpande . John K. C. Chan . J. Godfrey Heathcote . Rob Aalberse . Atsushi Azumi . Donald B. Bloch . William R. Brugge . Mollie N. Carruthers . Wah Cheuk . Lynn Cornell . Carlos Fernandez-Del Castillo . Judith A. Ferry . David Forcione . Günter Klöppe . Daniel L. Hamilos . Terumi Kamisawa . Satomi Kasashima . Shigeyuki Kawa . Mitsuhiro Kawano . Yasufumi Masaki . Kenji Notohara . Kazuichi Okazaki . Ji Kon Ryu . Takako Saeki . Dushyant Sahani . Yasuharu Sato . Thomas Smyrk . James R. Stone . Masayuki Takahira . Hisanori Umehara . George Webster . Motohisa Yamamoto . Eunhee Yi . Tadashi Yoshino . Giuseppe Zamboni . Yoh Zen . Suresh Chari . October 2012 . Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations . . 64 . 10 . 3061–3067 . 10.1002/art.34593 . 22736240. 5963880 .