Mikes Creek is a stream in Barry and McDonald counties of the Ozarks of southwestern Missouri.
The headwaters are in western Barry County at 36.7228°N -94.0578°W and the confluence with Big Sugar Creek is in McDonald County at 36.6242°N -94.1867°W. The source of the stream is in western Barry County to the southeast of Rocky Comfort in northeast McDonald County. The stream flows southwest paralleling Missouri Route U then turns west to its confluence just northwest of Powell.[1] Some say Mike's Creek was named after an elderly settler named Mike, while others believe the name is a corruption of Michael, the surname of Phillip Michael, a pioneer citizen.[2]