| Mike Santiago | |
| Birth Date: | 1 October 1955 |
| Birth Place: | Baltimore, Maryland, U.S. |
| Death Place: | San Antonio, Texas, U.S. |
| Player Years1: | 1973–1974 |
| Player Team1: | Glendale |
| Player Years2: | 1975–1976 |
| Player Team2: | Southern Utah |
| Player Positions: | Defensive back |
| Coach Years1: | 1978 |
| Coach Team1: | Lamar (SA) |
| Coach Years2: | 1979 |
| Coach Team2: | Lamar (WR) |
| Coach Years3: | 1980–1981 |
| Coach Team3: | Lamar (JV/WR) |
| Coach Years4: | 1982 |
| Coach Team4: | NC State (WR) |
| Coach Years5: | 1983 |
| Coach Team5: | Northern Arizona (WR) |
| Coach Years6: | 1984 |
| Coach Team6: | Cleveland Browns (scout) |
| Coach Years7: | 1985–1986 |
| Coach Team7: | Western Michigan (WR) |
| Coach Years8: | 1987–1989 |
| Coach Team8: | Southwest Texas State (QB/WR) |
| Coach Years9: | 1990–1998 |
| Coach Team9: | McNeese State (OC/QB) |
| Coach Years10: | 1999–2004 |
| Coach Team10: | Stephen F. Austin |
| Coach Years11: | 2005–2006 |
| Coach Team11: | Utah State (OC/QB) |
| Coach Years12: | 2009–2011 |
| Coach Team12: | Incarnate Word |
| Coach Years13: | 2017–2022 |
| Coach Team13: | Central Catholic HS (TX) |
| Overall Record: | 49–45 (college) |
| Championships: | 1 Southland (1999) |
Michael Edward Santiago (October 1, 1955 – August 10, 2023) was an American football coach. He served as head football coach at Stephen F. Austin State University (SFA) from 1999 to 2004, and the University of the Incarnate Word (UIW) from 2009 through 2011, compiling a career college football head coaching record of 49–45. He was also head football coach of Central Catholic High School in San Antonio from 2017 until his death from cancer, in 2023, at the age of 67.[1] [2] [3] [4]