Mihai Ioan Botez Explained

Mihai Ioan Botez (29 June 1927 – 2 June 1998) was born in Ploiești, Romania, trained at Carol Davila University of Medicine and Pharmacy, a neurologist and academic who specialized in the field of neuropsychology. He immigrated to Montreal in the 1970s, becoming a professor at the Université de Montréal and director of the department of Neurology at the hospital Hôtel-Dieu de Montréal.

Academic life

Botez trained at the Romanian School of Neurology founded by Gheorghe Marinescu. He immigrated to Canada in the 1970s, where he became professor of neurology at the Université de Montréal and head of the Neurology Service at the hospital Hôtel-Dieu de Montréal.[1] [2] From 1985, his main work featured the role of the cerebellum on human behavior.[3]

Behavioral neurology

Botez became a proficient researcher in several fields of behavioral neurology in both human and animal subjects.[4]

Folic acid

In the 1970s, Botez' main research subject was the effects of folic acid and thiamine on the central nervous system, relevant for restless legs syndrome, epilepsy, polyneuropathy, and chronic fatigue syndrome.[5] [6] [7] These articles demonstrated the use of B vitamins in the treatment of neurologic symptoms.

Cerebellum

In the 1980s, Botez pioneered studies on the effects of lesions to the cerebellum on cognition, including patients with spinocerebellar ataxia, Friedreich's ataxia, and mice with spontaneous mutations causing cerebellar damage, such as GRID2-Lc Lurcher.[8] [9] [10] [11] [12] [13] [14] These articles demonstrated the role of the cerebellum in neuropsychology.

Neurochemistry

Together with neurochemists Simon N Young of the Allan Memorial Institute and Tomas A Reader of the Université de Montréal, Botez obtained measures of brain concentrations of neurotransmitters such as biogenic amine metabolites of dopamine, norepinephrine, and serotonin in patients, as well as concentrations and receptor density of these neurotransmitters and glutamic acid in mouse brain, he and his co-workers in neurochemistry provided vital cues to underlying neurochemical abnormalities in patients with B vitamin anomalies and patients with cerebellar atrophy.[15] [16] [17] [18] Such studies lead to successful trials with amantadine, a substance facilitating dopamine transmission, to ameliorate reaction times in cerebellar atrophy,[19] as well as respiratory failure.[20]

Notes and References

  1. Web site: Hommage posthume au Dr. Mihai-Ioan Botez . Léveillé . Jean . L'Association des médecins de langue française du Canada . unfit . https://web.archive.org/web/20040913220304/http://www.amlfc.org/Articles/1998_11_03.html . September 13, 2004 .
  2. Forum, Université de Montréal, 1987, vol 21, no 28, p 1.
  3. Forum, Université de Montréal, 1989, vol 24, no 10, p 5.
  4. MI Botez (éd) Neuropsychologie clinique et neurologie du comportement. Paris: Presses de l’Université de Montréal et Masson, 2e éd., pp 319-337, 1996.
  5. Botez MI, Peyronnard JM, Bachevalier J, Charron L . Polyneuropathy and folate deficiency . Archives of Neurology . 35 . 9 . 581–4 . September 1978 . 210747 . 10.1001/archneur.1978.00500330029005 .
  6. Botez MI, Peyronnard JM, Bérubé L, Labrecque R . Relapsing neuropathy, cerebral atrophy and folate deficiency. A close association . Applied Neurophysiology . 42 . 3 . 171–83 . 1979 . 464598 . 10.1159/000102361.
  7. Botez MI, Fontaine F, Botez T, Bachevalier J . Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies . European Neurology . 16 . 1–6 . 230–46 . 1977 . 615714 . 10.1159/000114904.
  8. Botez MI, Pedraza OL, Botez-Marquard T, Vézina JL, Elie R . Radiologic correlates of reaction time measurements in olivopontocerebellar atrophy . European Neurology . 33 . 4 . 304–9 . 1993 . 8348918 . 10.1159/000116959.
  9. Botez-Marquard T, Botez MI . Olivopontocerebellar atrophy and Friedreich's ataxia: neuropsychological consequences of bilateral versus unilateral cerebellar lesions . International Review of Neurobiology . 41 . 387–410 . 1997 . 9378599 . 10.1016/S0074-7742(08)60361-X.
  10. Botez MI . Cerebellum and non-motor behaviour . Romanian Journal of Neurology and Psychiatry . 31 . 3–4 . 189–93 . 1993 . 8011482.
  11. Botez-Marquard T, Botez MI . Cognitive behavior in heredodegenerative ataxias . European Neurology . 33 . 5 . 351–7 . 1993 . 8243509 . 10.1159/000116970.
  12. Lalonde R, Botez MI . The cerebellum and learning processes in animals . Brain Research. Brain Research Reviews . 15 . 3 . 325–32 . 1990 . 2289089 . 10.1016/0165-0173(90)90006-A.
  13. Botez MI, Botez T, Elie R, Attig E . Role of the cerebellum in complex human behavior . Italian Journal of Neurological Sciences . 10 . 3 . 291–300 . June 1989 . 2767936 . 10.1007/BF02333774.
  14. Botez MI, Gravel J, Attig E, Vézina JL . Reversible chronic cerebellar ataxia after phenytoin intoxication: possible role of cerebellum in cognitive thought . Neurology . 35 . 8 . 1152–7 . August 1985 . 4022349 . 10.1212/wnl.35.8.1152.
  15. Botez MI, Young SN . Biogenic amine metabolites and thiamine in cerebrospinal fluid in heredo-degenerative ataxias . The Canadian Journal of Neurological Sciences . 28 . 2 . 134–40 . May 2001 . 11383938 . https://archive.today/20120709072432/http://cjns.metapress.com/openurl.asp?genre=article&issn=0317-1671&volume=28&issue=2&spage=134 . dead . July 9, 2012 . 2010-04-10 .
  16. Botez MI, Young SN . Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid . Brain . 114 . 1A . 333–48 . February 1991 . 1705463 .
  17. Reader TA, Strazielle C, Botez MI, Lalonde R . Brain dopamine and amino acid concentrations in Lurcher mutant mice . Brain Research Bulletin . 45 . 5 . 489–93 . March 1998 . 9570718 . 10.1016/S0361-9230(97)00430-9.
  18. Strazielle C, Lalonde R, Riopel L, Botez MI, Reader TA . Regional distribution of the 5-HT innervation in the brain of normal and lurcher mice as revealed by [3H]citalopram quantitative autoradiography . Journal of Chemical Neuroanatomy . 10 . 2 . 157–71 . April 1996 . 8783044 . 10.1016/0891-0618(96)00115-9.
  19. Botez MI, Botez-Marquard T, Elie R, Le Marec N, Pedraza OL, Lalonde R . Amantadine hydrochloride treatment in olivopontocerebellar atrophy: a long-term follow-up study . European Neurology . 41 . 4 . 212–5 . 1999 . 10343152 . 10.1159/000008053.
  20. Botez MI, Mayer P, Bellemare F, Couture J . Can we treat respiratory failure in Friedreich ataxia? . Archives of Neurology . 54 . 8 . 1030–3 . August 1997 . 9267979 . 10.1001/archneur.1997.00550200086015 .

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