| Middle Island | |
| Location: | Ohio River, West Virginia, United States |
| Coordinates: | 39.407°N -81.2007°W |
| Country: | United States |
| Pushpin Map: | USA West Virginia |
Middle Island is a bar island on the Ohio River at St. Marys in Pleasants County, West Virginia, USA.
Middle Island lends its name to West Virginia's Middle Island Creek and lies at its confluence with "The Thoroughfare", a channel of the Ohio River that separates the island from the riverbank. A bridge (currently being renovated in 2019) connects Middle Island to downtown St. Marys. Middle Island is protected as part of the Ohio River Islands National Wildlife Refuge.[1]