| Middle Branch Piscataquog River | |
| Pushpin Map: | New Hampshire#USA |
| Pushpin Map Size: | 250 px |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | New Hampshire |
| Subdivision Type3: | County |
| Subdivision Name3: | Hillsborough |
| Subdivision Type4: | Towns |
| Subdivision Name4: | Francestown, New Boston, Weare |
| Length: | 10.6miles |
| Source1: | Haunted Lake |
| Source1 Location: | Francestown |
| Source1 Coordinates: | 42.9883°N -71.7594°W |
| Source1 Elevation: | 635feet |
| Mouth: | South Branch Piscataquog River |
| Mouth Location: | New Boston |
| Mouth Coordinates: | 43.0008°N -71.6608°W |
| Mouth Elevation: | 335feet |
| Tributaries Left: | Buxton Brook, Peacock Brook, Meadow Brook |
The Middle Branch of the Piscataquog River is a 10.6adj=midNaNadj=mid[1] river in southern New Hampshire in the United States. It is a tributary of the South Branch Piscataquog River, part of the Merrimack River watershed.
The Middle Branch begins at the outlet of Haunted Lake in the eastern part of Francestown. The river travels east-northeast through the town of New Boston, entering Weare, where it turns abruptly south to reenter New Boston and join the South Branch.