Microtubule-severing ATPase explained

microtubule-severing ATPase
Ec Number:	3.6.4.3
Go Code:	0008568

In enzymology, a microtubule-severing ATPase is an enzyme that catalyzes the chemical reaction

ATP + H₂O

\rightleftharpoons ADP + phosphate

Thus, the two substrates of this enzyme are ATP and H₂O, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to facilitate cellular and subcellular movement. The systematic name of this enzyme class is ATP phosphohydrolase (tubulin-dimerizing).

See also

• Katanin

References

• McNally FJ, Vale RD . 1993 . Identification of katanin, an ATPase that severs and disassembles stable microtubules . Cell . 75 . 419 - 29 . 8221885 . 10.1016/0092-8674(93)90377-3 . 3 .
• Cheesman S, Heuser J, Vale RD, McNally FJ . 1998 . Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit . Cell . 93 . 277 - 87 . 9568719 . 10.1016/S0092-8674(00)81578-0 . 2 . free .