Microphthalmia–dermal aplasia–sclerocornea syndrome explained

Synonym:	MIDAS syndrome

Microphthalmia–dermal aplasia–sclerocornea syndrome is a condition characterized by linear skin lesions.^{[1] [2]} MLS is a rare X-linked dominant male-lethal disease characterized by unilateral or bilateral microphthalmia and linear skin defects in affected females, and in utero lethality for affected males. It can be associated with HCCS,^[3] mutations in it cause microphthalmia with Linear Skin Defects Syndrome.^[4]

See also

• List of cutaneous conditions

External links

• GeneReview/NIH/UW entry on Microphthalmia with Linear Skin Defects Syndrome

Notes and References

1. Book: Rapini, Ronald P. . Bolognia, Jean L. . Jorizzo, Joseph L. . Dermatology: 2-Volume Set . Mosby . St. Louis . 2007 . 978-1-4160-2999-1 .
2. 5 . 47 . 710–3 . 1993 . 10.1002/ajmg.1320470525 . 8267001 . American Journal of Medical Genetics . MIDAS syndrome (microphthalmia, dermal aplasia, and sclerocornea): an X-linked phenotype distinct from Goltz syndrome . Daniëls . R. . O. . Koopman . R. J. J. . Happle.
3. Wimplinger I, Morleo M, Rosenberger G, etal . Mutations of the mitochondrial holocytochrome c-type synthase in X-linked dominant microphthalmia with linear skin defects syndrome . Am. J. Hum. Genet. . 79 . 5 . 878–89 . November 2006 . 17033964 . 1698567 . 10.1086/508474 .
4. Wimplinger I, Morleo M, Rosenberger G, Iaconis D, Orth U, Meinecke P, Lerer I, Ballabio A, Gal A, Franco B, Kutsche K . Mutations of the mitochondrial holocytochrome c-type synthase in X-linked dominant microphthalmia with linear skin defects syndrome . Am. J. Hum. Genet. . 79 . 5 . 878–89 . 2006 . 17033964 . 1698567 . 10.1086/508474 .