MicroRNA 93 explained

MicroRNA 93 is a functional RNA and a microRNA that in humans is encoded by the MIR93 gene.^[1]

Function

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70 nucleotide long stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target messenger RNAs (mRNA) through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.^[2]

Further reading

• Petrocca F, Visone R, Onelli MR, Shah MH, Nicoloso MS, de Martino I, Iliopoulos D, Pilozzi E, Liu CG, Negrini M, Cavazzini L, Volinia S, Alder H, Ruco LP, Baldassarre G, Croce CM, Vecchione A . E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer . Cancer Cell . 13 . 3 . 272–86 . March 2008 . 18328430 . 10.1016/j.ccr.2008.02.013 . free .
• Yeung ML, Yasunaga J, Bennasser Y, Dusetti N, Harris D, Ahmad N, Matsuoka M, Jeang KT . Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1 . Cancer Res. . 68 . 21 . 8976–85 . November 2008 . 18974142 . 2596768 . 10.1158/0008-5472.CAN-08-0769 .
• Li Y, Tan W, Neo TW, Aung MO, Wasser S, Lim SG, Tan TM . Role of the miR-106b-25 microRNA cluster in hepatocellular carcinoma . Cancer Sci. . 100 . 7 . 1234–42 . July 2009 . 19486339 . 10.1111/j.1349-7006.2009.01164.x . 39583369 . free .
• Du L, Schageman JJ, Subauste MC, Saber B, Hammond SM, Prudkin L, Wistuba II, Ji L, Roth JA, Minna JD, Pertsemlidis A . miR-93, miR-98, and miR-197 regulate expression of tumor suppressor gene FUS1 . Mol. Cancer Res. . 7 . 8 . 1234–43 . August 2009 . 19671678 . 2741087 . 10.1158/1541-7786.MCR-08-0507 .
• Shen J, DiCioccio R, Odunsi K, Lele SB, Zhao H . Novel genetic variants in miR-191 gene and familial ovarian cancer . BMC Cancer . 10 . 47 . February 2010 . 20167074 . 2831822 . 10.1186/1471-2407-10-47 . free .
• Roccaro AM, Sacco A, Jia X, Azab AK, Maiso P, Ngo HT, Azab F, Runnels J, Quang P, Ghobrial IM . microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia . Blood . 116 . 9 . 1506–14 . September 2010 . 20519629 . 2938840 . 10.1182/blood-2010-01-265686 .
• Hu Z, Shu Y, Chen Y, Chen J, Dong J, Liu Y, Pan S, Xu L, Xu J, Wang Y, Dai J, Ma H, Jin G, Shen H . Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival . Am. J. Respir. Crit. Care Med. . 183 . 5 . 641–8 . March 2011 . 20889907 . 10.1164/rccm.201005-0717OC .
• Fang L, Deng Z, Shatseva T, Yang J, Peng C, Du WW, Yee AJ, Ang LC, He C, Shan SW, Yang BB . MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8 . Oncogene . 30 . 7 . 806–21 . February 2011 . 20956944 . 10.1038/onc.2010.465 . free .
• Choi OR, Lim IK . Loss of p21(Sdi1) expression in senescent cells after DNA damage accompanied with increase of miR-93 expression and reduced p53 interaction with p21(Sdi1) gene promoter . Biochem. Biophys. Res. Commun. . 407 . 2 . 406–11 . April 2011 . 21402054 . 10.1016/j.bbrc.2011.03.038 .

Notes and References

1. Web site: Entrez Gene: MicroRNA 93. 2018-10-24.
2. RefSeq, Sep 2009