MicroRNA 425 explained

MicroRNA 425 is a microRNA that in humans is encoded by the MIR425 gene.^[1]

Further reading

• Liang D, Meyer L, Chang DW, Lin J, Pu X, Ye Y, Gu J, Wu X, Lu K . Genetic variants in MicroRNA biosynthesis pathways and binding sites modify ovarian cancer risk, survival, and treatment response . Cancer Res. . 70 . 23 . 9765–76 . December 2010 . 21118967 . 5373101 . 10.1158/0008-5472.CAN-10-0130 .
• Di Leva G, Piovan C, Gasparini P, Ngankeu A, Taccioli C, Briskin D, Cheung DG, Bolon B, Anderlucci L, Alder H, Nuovo G, Li M, Iorio MV, Galasso M, Santhanam R, Ramasamy S, Marcucci G, Perrotti D, Powell KA, Bratasz A, Garofalo M, Nephew KP, Croce CM . Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status . PLOS Genet. . 9 . 3 . e1003311 . 2013 . 23505378 . 3591271 . 10.1371/journal.pgen.1003311 . free .
• Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ . Atrial natriuretic peptide is negatively regulated by microRNA-425 . J. Clin. Invest. . 123 . 8 . 3378–82 . August 2013 . 23867623 . 3726159 . 10.1172/JCI67383 .
• Ma J, Liu J, Wang Z, Gu X, Fan Y, Zhang W, Xu L, Zhang J, Cai D . NF-kappaB-dependent microRNA-425 upregulation promotes gastric cancer cell growth by targeting PTEN upon IL-1β induction . Mol. Cancer . 13 . 40 . February 2014 . 24571667 . 3941686 . 10.1186/1476-4598-13-40 . free .
• Peng WZ, Ma R, Wang F, Yu J, Liu ZB . Role of miR-191/425 cluster in tumorigenesis and diagnosis of gastric cancer . Int J Mol Sci . 15 . 3 . 4031–48 . March 2014 . 24603541 . 3975382 . 10.3390/ijms15034031 . free .
• Moskwa P, Zinn PO, Choi YE, Shukla SA, Fendler W, Chen CC, Lu J, Golub TR, Hjelmeland A, Chowdhury D . A functional screen identifies miRs that induce radioresistance in glioblastomas . Mol. Cancer Res. . 12 . 12 . 1767–78 . December 2014 . 25256711 . 4386891 . 10.1158/1541-7786.MCR-14-0268 .
• Liu P, Hu Y, Ma L, Du M, Xia L, Hu Z . miR-425 inhibits melanoma metastasis through repression of PI3K-Akt pathway by targeting IGF-1 . Biomed. Pharmacother. . 75 . 51–7 . October 2015 . 26463631 . 10.1016/j.biopha.2015.08.010 .
• Zhang Y, Hu X, Miao X, Zhu K, Cui S, Meng Q, Sun J, Wang T . MicroRNA-425-5p regulates chemoresistance in colorectal cancer cells via regulation of Programmed Cell Death 10 . J. Cell. Mol. Med. . 20 . 2 . 360–9 . February 2016 . 26647742 . 4727563 . 10.1111/jcmm.12742 .
• Liu L, Zhao Z, Zhou W, Fan X, Zhan Q, Song Y . Enhanced Expression of miR-425 Promotes Esophageal Squamous Cell Carcinoma Tumorigenesis by Targeting SMAD2 . J Genet Genomics . 42 . 11 . 601–611 . November 2015 . 26674378 . 10.1016/j.jgg.2015.09.010 .

Notes and References

1. Web site: Entrez Gene: MicroRNA 425. 2018-10-11.