Michela Gallagher Explained

Michela Gallagher
Workplaces:University of North Carolina–Chapel Hill, Johns Hopkins University, AgeneBio
Alma Mater:University College London, Colgate University, University of Vermont
Thesis Title:The effects of norepinephrine manipulations in the amygdala on time-dependent memory processes
Thesis Url:https://library.uvm.edu/collections/theses?search_type=item&bid=591962
Thesis Year:1977
Awards:Mika Salpeter Lifetime Achievement Award

Michela Gallagher is an American cognitive psychologist and neuroscientist. She is the Krieger-Eisenhower Professor of Psychology and Neuroscience at Johns Hopkins University. Her scientific work has changed the model of neurocognitive aging, and developed new indices for its study. Previously, work had focused on neurodegeneration as a primary cause of memory loss.

Gallagher's research suggests that age-related declines in cognition may also occur in the absence of neurodegeneration, due to malfunctioning rather than dying off. Gallagher is also the founder and CEO of AgeneBio, a company which aims to develop a cure for Alzheimer's disease.

Education and career

Gallagher did her first degree at University College London, where she majored in fine art. She transferred to Colgate University in New York in her last year.[1] She graduated from Colgate University in 1969, in its first class to include women. She was among the first two women at Colgate to receive a Bachelor of Arts degree, and she was the first woman to go on to receive her doctorate.

Her interest in the visual arts sparked her interest in the visual system and neuroscience, and she also became interested in memory. Gallagher went on to the University of Vermont, graduating with a PhD in neuroscience in 1977. Her thesis was titled The effects of norepinephrine manipulations in the amygdala on time-dependent memory processes.[2] [3]

Gallagher then worked at the University of North Carolina–Chapel Hill, where she was the Kenan Professor of Psychology. She joined Johns Hopkins University in 1997.[4] [5] She became the chair of the Department of Psychological and Brain Science at Johns Hopkins in 2000, holding the position until 2007.[6] She became the Krieger-Eisenhower Professor of Psychology and Neuroscience in 2003.[7] She became Vice Provost of Academic Affairs in 2008,[8] holding the appointment for four years. She also leads the Neurogenetics and Behavior Center, located at Johns Hopkins University.[9]

Gallagher was the editor-in-chief of Behavioral Neuroscience from 1995 to 2001.[10] She is a member of the American Association for the Advancement of Science (AAAS),[5] and a fellow of the American Psychological Association (APA),[11] the Association for Psychological Science, and the Society for Neuroscience (SfN) among others.She founded AgeneBio in 2008, which focuses on finding new treatments for Alzheimer's disease.

Research

Gallagher studies age-related changes in the brain. Her scientific work has changed the model of neurocognitive aging.[12] Beginning in the 1950s, work had focused on neurodegeneration as a primary cause of memory loss. Gallagher's research suggests that brain cells are malfunctioning rather than just dying off. This has led researchers to investigate a wide range of neural mechanisms and different possible interventions.[10] [12]

Over a number of years, Gallagher has developed a model for the controlled study of natural aging and age-related memory loss, using Long-Evans rats. The rats are bred to age well, and Gallagher studies them over their entire lifetime. During that time, they are carefully looked after, and protected from exposure to germs and viruses. Measures of the rats' memory and cognition abilities have been developed for use in water mazes.[10]

With Rebecca Burwell and Margaret Burchinal (1993), Gallagher developed new measures of spatial learning for use with the Morris water navigation task (often referred to as the Morris water maze).[13] These included "the cumulative search error during learning trials, the average proximity during probe trials, and the spatial learning index to quantify overall learning of the task across days."[14] [15] The impact of these measures in the field is significant.[14] Researchers reference measures such as "Gallagher’s proximity-index"[16] and the "Gallagher-Baker indices".[17]

One of Gallagher's fields of study is hyperactivity in the hippocampus,[18] [19] which occurs in patients with Alzheimer's disease, and may cause amnestic mild cognitive impairment.[20] [21] She found that aging rats with hyperactivity in the hippocampus caused difficulties in completing a memory task.[22] [23] Giving these rats levetiracetam reduced these impairments.[20]

Gallagher started the company AgeneBio, which studies treatments for mild cognitive impairment in patients with Alzheimer's disease.[24] One of the therapeutics the company researches is AGB-101, a form of levetiracetam, which targets neuronal hyperactivity in the hippocampus.[25] [26] This drug was developed for use in epilepsy.[27] [28] For this work Gallagher received the Melvin R. Goodes Prize for Excellence in Alzheimer's Drug Discovery from the Alzheimer's Drug Discovery Foundation. In addition, the company is studying a drug called GABA-A a5 PAM, which also targets hyperactivity in the hippocampus.[29] [30] In 2019 the company received a $3.4m grant for this work.

Honors

Selected publications

Notes and References

  1. Web site: She's the One . Colgate Magazine . Aleta . Mayne. 1 November 2019. en-US. 7 March 2020.
  2. Web site: Honorary Degree Recipient: Michela Gallagher. University of Vermont . en. 7 March 2020. 2019.
  3. Web site: UVM Theses and Dissertations Howe Library. University of Vermont Libraries . 7 March 2020.
  4. Web site: CHAIRS and PANELISTS . Reserve and Resilience . 23 March 2020.
  5. Gallagher Ably Filling Olton's Shoes. Emil Venere . Homewood . 23 March 2020 . The Gazette. The Johns Hopkins University . 9 June 1997. 26. 37.
  6. Web site: Krieger-Eisenhower Professorships . Johns Hopkins University . 11 July 2016 . 23 March 2020.
  7. News: Five Profs Named to Krieger-Eisenhower Chairs . 23 March 2020 . The Gazette. The Johns Hopkins University . 38. 32 . 23 June 2003.
  8. Web site: Periodic Review Report presented by Johns Hopkins University Ronald J. Daniels, President presented to Middle States Commission on Higher Education June 1, 2009. 1 June 2009. 4 . The Johns Hopkins University . 23 March 2020.
  9. Web site: Dr. Michela Gallagher Wins Alzheimer's Drug Discovery Foundation's Prestigious Goodes Prize Alzheimer's Drug Discovery Foundation. Alzheimer's Drug Discovery Foundation . en. 7 March 2020.
  10. Purdy . Michael . Gray Matters . 23 March 2020 . Johns Hopkins Magazine . 2001. 53. 3.
  11. Packard . Erika . A Closer Look The biology of behavior . Monitor on Psychology . 2007 . 38 . 7 . 86 . 23 March 2020.
  12. Web site: Michela Gallagher, PhD,Johns Hopkins University, PLENARY PRESENTATION . 13. 10th International Conference on Alzheimer’s Drug Discovery, 14–15 September 2009, Jersey City, New Jersey. 2009 . 23 March 2020.
  13. Gallagher . Michela . Burwell . Rebecca . Burchinal . Margaret R. . Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze. . Behavioral Neuroscience . 1993 . 107 . 4 . 618–626 . 10.1037/0735-7044.107.4.618. 26214219 . 5640430 .
  14. Tomás Pereira. Inês . Burwell . Rebecca D. . Using the spatial learning index to evaluate performance on the water maze. . Behavioral Neuroscience . August 2015 . 129 . 4 . 533–539 . 10.1037/bne0000078 . 26214218 . 5077721 . free .
  15. Book: Foreman . Nigel . Gillett . Raphael . Handbook of spatial research. Paradigms and methodologies . 1997 . Psychology Press . 9781138877269 . 150 .
  16. Book: Bimonte-Nelson . Heather A. . The maze book : theories, practice, and protocols for testing rodent cognition . 2015 . Springer . New York Heidelberg Dordrecht London . 978-1-4939-2158-4 . 80.
  17. Web site: What are the Gallagher-Baker indices in Water Maze? . HVS Image . 23 March 2020.
  18. Web site: Reducing brain activity improves memory after cognitive decline. ScienceDaily . en. 7 March 2020.
  19. Book: Stern . Robert A. . Alosco . Michael L. . The Oxford handbook of adult cognitive disorders . 7 May 2019 . Oxford University Press . 9780190664145 . 7–10 . 21 May 2020.
  20. Setti . Sharay E. . Hunsberger . Holly C. . Reed . Miranda N. . Alterations in hippocampal activity and Alzheimer's disease. . Translational Issues in Psychological Science . December 2017 . 3 . 4 . 348–356 . 10.1037/tps0000124 . 29862310 . 5972837 .
  21. Stargardt. Anita. Swaab. Dick F.. Bossers. Koen. 1 January 2015. The storm before the quiet: neuronal hyperactivity and Aβ in the presymptomatic stages of Alzheimer's disease. Neurobiology of Aging. en. 36. 1. 1–11. 10.1016/j.neurobiolaging.2014.08.014. 25444609. 207161688. 0197-4580.
  22. McGarrity . Stephanie . Mason . Rob . Fone . Kevin C. . Pezze . Marie . Bast . Tobias . Hippocampal Neural Disinhibition Causes Attentional and Memory Deficits . Cerebral Cortex . 22 August 2016 . 27 . 9 . 4447–4462 . 10.1093/cercor/bhw247 . 27550864 . free .
  23. Koh. Ming Teng. Haberman. Rebecca P.. Foti. Stacey. McCown. Thomas J.. Gallagher. Michela. 2010. Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment. Neuropsychopharmacology. 35. 4. 1016–1025. 10.1038/npp.2009.207. 1740-634X. 2820138. 20032967.
  24. Web site: Aguirre. Lauren. The Role of Seizures in Alzheimer's Disease Is Gaining Overdue Attention. 23 June 2020. Scientific American. en.
  25. Web site: More Evidence That Epilepsy Drug Calms Neurons and Boosts Memory ALZFORUM. www.alzforum.org. 7 March 2020.
  26. Bakker. Arnold. Krauss. Gregory L.. Albert. Marilyn S.. Speck. Caroline L.. Jones. Lauren R.. Stark. Craig E.. Yassa. Michael A.. Bassett. Susan S.. Shelton. Amy L.. Gallagher. Michela. 10 May 2012. Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron. 74. 3. 467–474. 10.1016/j.neuron.2012.03.023. 0896-6273. 3351697. 22578498.
  27. Web site: Phase 3 Trial of AGB101 Targets Hippocampal Hyperactivity to Slow Progression of MCI. Neurology Live. 7 March 2020.
  28. Web site: This JHU startup is working on a treatment to prevent Alzheimer's. Babcock. Stephen. 17 September 2015. Technical.ly Baltimore. en. 7 March 2020.
  29. Web site: AgeneBio receives $3.4M for development of Alzheimer's treatment. Babcock. Stephen. 13 September 2019. Technical.ly Baltimore. en. 7 March 2020.
  30. AgeneBio Announces Additional Funding to Advance Novel GABA-A Therapeutic Program to Address Alzheimer's and Other CNS Conditions. www.prnewswire.com. en. 7 March 2020.
  31. Book: Klein . Stephen B. . Learning : principles and applications . 2014 . SAGE Publications . 978-1452271941 . 63–64 . 7thition . 23 March 2020.
  32. Web site: Johns Hopkins neuroscientist Michela Gallagher to receive Lifetime Achievement Award. Reeves. Tracey. 17 November 2014. The Hub. en. 7 March 2020.
  33. Web site: Awards Pavlovian Society. en-US. 7 March 2020.
  34. Web site: T.J. Oshie and Dr. Michela Gallagher Honored at Ninth Annual Great Ladies Luncheon. markets.businessinsider.com. 7 March 2020.

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