| Michel-Siméon Delisle | |
| Smallimage: | Michel-Siméon Delisle.jpg |
| Constituency Mp: | Portneuf |
| Parliament: | Canadian |
| Predecessor: | Henri-Gustave Joly de Lotbinière |
| Successor: | Jules Desrochers |
| Term Start: | 1900 |
| Term End: | 1930 |
| Birth Date: | 27 September 1856 |
| Birth Place: | Pointe-aux-Trembles, Portneuf County, Canada East |
| Party: | Liberal |
Michel-Siméon Delisle (September 27, 1856 - October 11, 1931) was a Canadian merchant and politician.
Born in Pointe-aux-Trembles, Portneuf County, Canada East, the son of Albert Delisle and Dina Bertrand, Delisle was educated in Quebec City. A merchant, he was Mayor of Portneuf for five years. He was first elected to the House of Commons of Canada at the general elections of 1900 and he was re-elected in 1904, 1908, 1911, 1917, 1925, and 1926. A Liberal, he served for almost 30 years for the riding of Portneuf.