Michael P. Snyder Explained

Michael Paul Snyder
Birth Date:1955
Birth Place:Pottstown, Pennsylvania
Nationality:American
Known For:RNA sequencing, ChIP-chip and CHIP-seq(11), genomics, pioneering multi-omic longitudinal health tracking, wearable technology, systems biology, systems medicine
Occupation:Geneticist, Stanford B. Ascherman Professor
chair of genetics department, Stanford University
director of the Center for Genomics and Personalized Medicine
Alma Mater:University of RochesterCalifornia Institute of Technology
Fields:Genetics, genomics, personalized medicine
Workplaces:Yale University
Stanford University
Doctoral Advisor:Dr. Norman Davidson
Academic Advisors:Dr. Ronald Davis[1]

Michael Paul Snyder is an American genomicist and the Stanford B. Ascherman Professor,[2] [3] and since 2009, chair of genetics and director of genomics and personalized medicine at Stanford University.[2] He is the former director of the Yale Center for Genomics and Proteomics.[1] He was elected to the American Academy of Arts and Sciences in 2015. During his tenure as chair of the department at Stanford, U.S. News & World Report has ranked Stanford University first or tied for first in genetics, genomics and bioinformatics.[4]

Snyder has co-founded companies in genetics, genomics, and personalized medicine, including Personalis,[5] a company that develops software to interpret genomes after sequencing; January AI,[6] a health startup; Protometrix;[7] Affomix;[8] and Q Bio.[9]

Snyder has been a principal investigator of the ENCODE project since its inception in 2003,[10] and co-director of the CIRM Center for Stem Cell Genomics[11] and director of the Center for Genome of Gene Regulation.[12]

Snyder pioneered the use of multi-omic longitudinal profiling to track health.[13] [14]

Early life and education

Snyder was born in 1955 and grew up outside of Pottstown, Pennsylvania.[15] [16] His father, Kermit Snyder, was an accountant and his mother, Phyllis Snyder, was an elementary school teacher. Snyder attended Owen J Roberts High school in Pottstown. He received a BA in chemistry and biology from the University of Rochester, NY on a scholarship.[17] He went on to receive a PhD in biology from the California Institute of Technology, where he trained in the laboratory of Norman Davidson.[18] Snyder completed his postdoctoral training at Stanford University School of Medicine in the laboratory of Ronald W. Davis.[18] There he was involved in several projects including establishment of successful cloning of genes using antibodies.

Career

Snyder worked at Yale University in 1986 as an assistant professor in the department of biology,[17] and was granted tenure in 1994. In 1998, the department of biology split and Snyder served as chair of the new molecular, cellular and developmental biology (MCDB) department until 2004.[18] His laboratory worked on chromosome segregation and cell polarity, and discovered a number of genes involved in these processes.[19] [20]

His laboratory proposed the first models by which eukaryotes select sites of cell growth.[21] [20]

In 2009, Snyder chaired the genetics department at Stanford University and directed the Center for Genomics and Personalized Medicine. Snyder was principal investigator of the Center of Excellence in the Genome Sciences (CEGS) from 2001 to 2011, was principal investigator for NIH Training Grants in Genomics and Proteomics (first at Yale, now at Stanford) from 2004, and is co-director of the CIRM Center for Stem Cell Genomics[22] and director for the Center for Genome of Gene Regulation.[23] Snyder was president of the US Human Proteome Organization from 2006 to 2008, and the international Human Proteome Organization from 2017 to 2018. He currently leads the National Institutes of Health's Encyclopedia of DNA Elements (ENCODE)'s production center for mapping regulatory regions of the human genome.[24]

Snyder has co-founded biotechnology companies, including Personalis,[5] SensOmics,[25] Qbio,[9] [26] [27] January AI,[6] Filtricine, Mirvie, Protos, Protometrix[7] (now part of Thermo Fisher Scientific), and Affomix[8] (now part of Illumina).[28]

Research

Snyder has made contributions to medicine, genomics and biotechnology. Snyder's laboratory has invented a number of novel systems-wide and genomics technologies. Snyder's laboratory at Yale initially focused on studying the genome of the yeast Saccharomyces cerevisiae, a eukaryote model organism commonly used in genetics and molecular biology.[29] Later, the lab began to use the same techniques to look at the human genome.

In 2003, the Encyclopedia of DNA Elements (ENCODE) project was launched by the US National Human Genome Research Institute (NHGRI), with the goal of identifying all functional elements in the human genome. He has been a principal investigator in the ENCODE project since its inception in 2003 and his lab has contributed a large number of data sets.

Selected publications

  1. Alavi, Arash, et al. Real-time alerting system for COVID-19 and other stress events using wearable data | Nature Medicine . Nature Medicine . January 2022 . 28 . 1 . 175–184 . 10.1038/s41591-021-01593-2 . Alavi . Arash . Bogu . Gireesh K. . Wang . Meng . Rangan . Ekanath Srihari . Brooks . Andrew W. . Wang . Qiwen . Higgs . Emily . Celli . Alessandra . Mishra . Tejaswini . Metwally . Ahmed A. . Cha . Kexin . Knowles . Peter . Alavi . Amir A. . Bhasin . Rajat . Panchamukhi . Shrinivas . Celis . Diego . Aditya . Tagore . Honkala . Alexander . Rolnik . Benjamin . Hunting . Erika . Dagan-Rosenfeld . Orit . Chauhan . Arshdeep . Li . Jessi W. . Bejikian . Caroline . Krishnan . Vandhana . McGuire . Lettie . Li . Xiao . Bahmani . Amir . Snyder . Michael P. . 34845389 . 8799466 . . Nature medicine 2021 Nov 29:1-0.
  2. Bahmani, Amir, et al. Bahmani . Amir . Alavi . Arash . Buergel . Thore . Upadhyayula . Sushil . Wang . Qiwen . Ananthakrishnan . Srinath Krishna . Alavi . Amir . Celis . Diego . Gillespie . Dan . Young . Gregory . Xing . Ziye . Nguyen . Minh Hoang Huynh . Haque . Audrey . Mathur . Ankit . Payne . Josh . Mazaheri . Ghazal . Li . Jason Kenichi . Kotipalli . Pramod . Liao . Lisa . Bhasin . Rajat . Cha . Kexin . Rolnik . Benjamin . Celli . Alessandra . Dagan-Rosenfeld . Orit . Higgs . Emily . Zhou . Wenyu . Berry . Camille Lauren . Van Winkle . Katherine Grace . Contrepois . Kévin . Ray . Utsab . Bettinger . Keith . Datta . Somalee . Li . Xiao . Snyder . Michael P. . A scalable, secure, and interoperable platform for deep data-driven health management . Nature Communications . Springer Science and Business Media LLC . 12 . 1 . 2021-10-01 . 2041-1723 . 34599181 . 8486823 . 10.1038/s41467-021-26040-1 . 5757. 2021NatCo..12.5757B .
  3. Mishra, Tejaswini, et al. Mishra . Tejaswini . Wang . Meng . Metwally . Ahmed A. . Bogu . Gireesh K. . Brooks . Andrew W. . Bahmani . Amir . Alavi . Arash . Celli . Alessandra . Higgs . Emily . Dagan-Rosenfeld . Orit . Fay . Bethany . Kirkpatrick . Susan . Kellogg . Ryan . Gibson . Michelle . Wang . Tao . Hunting . Erika M. . Mamic . Petra . Ganz . Ariel B. . Rolnik . Benjamin . Li . Xiao . Snyder . Michael P. . Pre-symptomatic detection of COVID-19 from smartwatch data . Nature Biomedical Engineering . Springer Science and Business Media LLC . 4 . 12 . 2020-11-18 . 2157-846X . 33208926 . 9020268 . 10.1038/s41551-020-00640-6 . 1208–1220.
  4. Robertson G, Hirst M, Bainbridge M, Bilenky M, Zhao Y, Zeng T, Euskirchen G, Bernier B, Varhol R, Delaney A, Thiessen N, …, Snyder M and Jones S. Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing - PubMed . 2007 . 17558387 . Robertson . G. . Hirst . M. . Bainbridge . M. . Bilenky . M. . Zhao . Y. . Zeng . T. . Euskirchen . G. . Bernier . B. . Varhol . R. . Delaney . A. . Thiessen . N. . Griffith . O. L. . He . A. . Marra . M. . Snyder . M. . Jones . S. . Nature Methods . 4 . 8 . 651–657 . 10.1038/nmeth1068 . 28531263 . . Nat Methods. 2007;4:651-7.
  5. Horak, Christine E., et al. GATA-1 binding sites mapped in the beta-globin locus by using mammalian chIp-chip analysis - PubMed . 2002 . 11867748 . Horak . C. E. . Mahajan . M. C. . Luscombe . N. M. . Gerstein . M. . Weissman . S. M. . Snyder . M. . Proceedings of the National Academy of Sciences of the United States of America . 99 . 5 . 2924–2929 . 10.1073/pnas.052706999 . 122449 . free . . Proceedings of the National Academy of Sciences 99.5 (2002): 2924-2929.
  6. The ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome - PubMed . 2012 . 22955616 . ENCODE Project Consortium . Nature . 489 . 7414 . 57–74 . 10.1038/nature11247 . 3439153 . 2012Natur.489...57T . . Nature. 2012. 489(7414): 57-74.
  7. Wang Z, Gerstein M, Snyder M. RNA-Seq: a revolutionary tool for transcriptomics - PubMed . 2009 . 19015660 . Wang . Z. . Gerstein . M. . Snyder . M. . Nature Reviews. Genetics . 10 . 1 . 57–63 . 10.1038/nrg2484 . 2949280 . . Nat Rev Genet. 2009 Jan;10(1):57-63. PMID 19015660.
  8. Hudson ME, Pozdnyakova I, Haines K, Mor G, Snyder M. Identification of differentially expressed proteins in ovarian cancer using high-density protein microarrays - PubMed . 2007 . 17954908 . Hudson . M. E. . Pozdnyakova . I. . Haines . K. . Mor . G. . Snyder . M. . Proceedings of the National Academy of Sciences of the United States of America . 104 . 44 . 17494–17499 . 10.1073/pnas.0708572104 . 2077284 . 2007PNAS..10417494H . free . . Proc Natl Acad Sci USA. 2007;104: 17494-9.
  9. Kasowski M, Grubert F, Heffelfinger C, Hariharan M, Asabere A, Waszak SM, Habegger L, Rozowsky J, Shi M, Urban AE, … Weissman SM, Gerstein MB, Korbel JO, Snyder M. Variation in transcription factor binding among humans - PubMed . 2010 . 20299548 . Kasowski . M. . Grubert . F. . Heffelfinger . C. . Hariharan . M. . Asabere . A. . Waszak . S. M. . Habegger . L. . Rozowsky . J. . Shi . M. . Urban . A. E. . Hong . M. Y. . Karczewski . K. J. . Huber . W. . Weissman . S. M. . Gerstein . M. B. . Korbel . J. O. . Snyder . M. . Science . 328 . 5975 . 232–235 . 10.1126/science.1183621 . 2938768 . . Science. 2010. 328(5975): 232-5. Epub 2010. PMID 20299548.
  10. Borneman AR, Gianoulis TA, Zhang ZD, Yu H, Rozowsky J, Seringhaus MR, Wang LY, Gerstein M, Snyder M. Divergence of transcription factor binding sites across related yeast species - PubMed . 2007 . 17690298 . Borneman . A. R. . Gianoulis . T. A. . Zhang . Z. D. . Yu . H. . Rozowsky . J. . Seringhaus . M. R. . Wang . L. Y. . Gerstein . M. . Snyder . M. . Science . 317 . 5839 . 815–819 . 10.1126/science.1140748 . 21535866 . . Science. 2007;317: 815-19.
  11. Chen R, Mias GI, Li-Pook-Than J, Jiang L, … Snyder M. Personal omics profiling reveals dynamic molecular and medical phenotypes - PubMed . 2012 . 22424236 . Chen . R. . Mias . G. I. . Li-Pook-Than . J. . Jiang . L. . Lam . H. Y. . Chen . R. . Miriami . E. . Karczewski . K. J. . Hariharan . M. . Dewey . F. E. . Cheng . Y. . Clark . M. J. . Im . H. . Habegger . L. . Balasubramanian . S. . O'Huallachain . M. . Dudley . J. T. . Hillenmeyer . S. . Haraksingh . R. . Sharon . D. . Euskirchen . G. . Lacroute . P. . Bettinger . K. . Boyle . A. P. . Kasowski . M. . Grubert . F. . Seki . S. . Garcia . M. . Whirl-Carrillo . M. . Gallardo . M. . Cell . 148 . 6 . 1293–1507 . 10.1016/j.cell.2012.02.009 . 3341616 . 1 . . Cell. 2012;148:1293-307.
  12. Li X, Dunn J, Salins D, Zhou G, Zhou W, Schüssler-Fiorenza Rose SM, Perelman D, Colbert E, Runge R, Rego S, Sonecha R, Datta S, McLaughlin T, Snyder M. Digital Health: Tracking Physiomes and Activity Using Wearable Biosensors Reveals Useful Health-Related Information - PubMed . 2017 . 28081144 . Li . X. . Dunn . J. . Salins . D. . Zhou . G. . Zhou . W. . Schüssler-Fiorenza Rose . S. M. . Perelman . D. . Colbert . E. . Runge . R. . Rego . S. . Sonecha . R. . Datta . S. . McLaughlin . T. . Snyder . M. P. . PLOS Biology . 15 . 1 . e2001402 . 10.1371/journal.pbio.2001402 . 5230763 . free . . 2017 Jan 12;15(1):e2001402. doi: 10.1371/journal.pbio.2001402. PMID 28081144

Book

Awards and honors

Notes and References

  1. Web site: Michael P. Snyder.
  2. Web site: Michael Snyder, Ph.D., STANFORD W. ASCHERMAN PROFESSOR OF GENETICS . 20 August 2015 . Stanford profiles. 19 April 2022.
  3. Web site: Congratulations to Michael Snyder for receiving the 2019 George W. Beadle Award!. 2 April 2019. 16 May 2022.
  4. Web site: Best Genetics Graduate Programs - US News Rankings . . https://web.archive.org/web/20230407171846/https://www.usnews.com/best-graduate-schools/top-science-schools/genetics-rankings . 2023-04-07 . live.
  5. News: A Geneticist's Research Turns Personal. Anne. Eisenberg. The New York Times . 2 June 2012. 16 May 2022.
  6. News: Here Come the Artificial Intelligence Nutritionists. Sandeep. Ravindran. The New York Times . 14 March 2022. 16 May 2022.
  7. Web site: Invitrogen Buys Protein Chip Maker Protometrix. 2 April 2004. Genomeweb. 16 May 2022.
  8. Web site: Michael Snyder . online.stanford.edu.
  9. News: What's your ageing type? The four ways we grow old. Anna. Maxted. 16 May 2022. www.thetimes.co.uk.
  10. 10.1038/s41586-020-2449-8. Perspectives on ENCODE. 2020. Abascal. Federico. Acosta. Reyes. Addleman. Nicholas J.. Adrian. Jessika. Afzal. Veena. Aken. Bronwen. Akiyama. Jennifer A.. Jammal. Omar Al. Amrhein. Henry. Anderson. Stacie M.. Andrews. Gregory R.. Antoshechkin. Igor. Ardlie. Kristin G.. Armstrong. Joel. Astley. Matthew. Banerjee. Budhaditya. Barkal. Amira A.. Barnes. If H. A.. Barozzi. Iros. Barrell. Daniel. Barson. Gemma. Bates. Daniel. Baymuradov. Ulugbek K.. Bazile. Cassandra. Beer. Michael A.. Beik. Samantha. Bender. M. A.. Bennett. Ruth. Bouvrette. Louis Philip Benoit. Bernstein. Bradley E.. 6. Nature. 583. 7818. 693–98. 32728248. 7410827. 2020Natur.583..693E.
  11. Web site: The CIRM Center of Excellence in Stem Cell Genomics (CESCG). 26 February 2015.
  12. Web site: Home . genomacrg.cl.
  13. Zhou W, Sailani MR, Contrepois K, Zhou Y, Ahadi S, Leopold SR, Zhang MJ, Rao V, Avina M, Mishra T, Johnson J, Lee-McMullen B, Chen S, Metwally AA, Tran TD, Nguyen H, Zhou X, Albright B, Hong BY, Petersen L, Bautista E, Hanson B, Chen L, Spakowicz D, Bahmani A, Salins D, Leopold B, Ashland M, Dagan-Rosenfeld O, Rego S, Limcaoco P, Colbert E, Allister C, Perelman D, Craig C, Wei E, Chaib H, Hornburg D, Dunn J, Liang L, Rose SM, Kukurba K, Piening B, Rost H, Tse D, McLaughlin T, Sodergren E, Weinstock GM, Snyder M. 6 . Longitudinal multi-omics of host-microbe dynamics in prediabetes . Nature . 569 . 7758 . 663–71 . May 2019 . 31142858 . 6666404 . 10.1038/s41586-019-1236-x . 2019Natur.569..663Z .
  14. Web site: How Multi-Omics Profiling Can Redefine Precision Health and Medicine - US. ThermoFisher Scientific.
  15. Web site: Michael P. Snyder. 16 May 2022.
  16. News: What Happens When One Man's Genome Is Revealed. Amy Dockser. Marcus. Wall Street Journal . 14 May 2012. 16 May 2022. www.wsj.com.
  17. News: Making It Personal: Geneticist Michael Snyder Puts a Face on Personalized Medicine. Kayt. Sukel. Pacific Standard. 16 May 2022.
  18. Web site: Congratulations to Michael Snyder for receiving the 2019 George W. Beadle Award! . Schmidt . Silke . 9 April 2019 . Genetics Society of America . 8 February 2021.
  19. Page BD, Snyder M . CIK1: a developmentally regulated spindle pole body-associated protein important for microtubule functions in Saccharomyces cerevisiae . Genes Dev . 6 . 8 . 1414–29 . August 1992 . 1644287 . 10.1101/gad.6.8.1414 . 24949358 . free .
  20. Roemer T, Madden K, Chang J, Snyder M . Selection of axial growth sites in yeast requires Axl2p, a novel plasma membrane glycoprotein . Genes Dev . 10 . 7 . 777–93 . April 1996 . 8846915 . 10.1101/gad.10.7.777 . free .
  21. Snyder M, Gehrung S, Page BD . Studies concerning the temporal and genetic control of cell polarity in Saccharomyces cerevisiae . J Cell Biol . 114 . 3 . 515–32 . August 1991 . 1860883 . 2289092 . 10.1083/jcb.114.3.515 .
  22. Web site: The CIRM Center of Excellence in Stem Cell Genomics (CESCG). 26 February 2015. California's Stem Cell Agency. 16 May 2022.
  23. Web site: Snyder awarded $7.1 million from genome institute. News Center. 16 May 2022.
  24. Web site: RePORT ⟩ RePORTER .
  25. Web site: SensOmics, See the Unseen. SensOmics, See the Unseen.
  26. Web site: Our Mission and Values. www.q.bio. 16 May 2022.
  27. Web site: Body Count. STANFORD. magazine. 17 November 2021. stanfordmag.org. 16 May 2022.
  28. Web site: Snyder Lab . Stanford.edu . 2 December 2021.
  29. News: Bechard . Deni Ellis . Body Count: How Michael Snyder's self-monitoring project could transform human health . 2 December 2021 . Stanford Magazine . December 2021.
  30. Web site: Directory of Scholars . pewtrusts.org . en.
  31. Web site: Yale's Snyder Awarded 2007 Connecticut Medal of Science. 12 June 2008.
  32. Web site: Michael Snyder. American Academy of Arts and Sciences. 13 September 2023 .

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