| Mike Manzini | |
| Fullname: | Michael Jethro Manzini |
| Height: | 1.780NaN0 |
| Birth Date: | 1972 11, df=yes |
| Birth Place: | Hoedspruit, South Africa |
| Position: | Defender |
| Youthyears2: | –1995 |
| Youthclubs1: | Welverdiend Eastern Rangers |
| Youthclubs2: | Might FC |
| Years1: | 1995–2009 |
| Clubs1: | Mamelodi Sundowns |
| Caps1: | 274 |
| Goals1: | 3 |
| Nationalyears1: | 1999 |
| Nationalteam1: | South Africa |
| Nationalcaps1: | 3 |
| Nationalgoals1: | 0 |
| Pcupdate: | 13 February 2012 |
| Ntupdate: | 13 February 2007 |
Mike Manzini (born 29 November 1972 in Hoedspruit, Limpopo) is a South African former association football defender. He spent his entire career at Premier Soccer League club Mamelodi Sundowns and also played for South Africa.
Manzini was Sundowns' ever-reliable and efficient captain who made well over 250 appearances for the club. His good work in defence often went unnoticed by onlookers but it was a sign of his experience, composure and superb reading of the play that he very rarely found himself having to make a last-gasp tackle or clearance.