Michael M. Gottesman Explained

Birth Date:7 October 1946
Birth Place:Jersey City, New Jersey, U.S.
Education:Harvard University
Awards:National Academy of Sciences
Fields:Biochemistry
Known For:Impact of silent polymorphisms on tertiary structure and function
Workplaces:Peter Dent Brigham Hospital, Boston; Harvard University; National Institutes of Health

Michael M. Gottesman (born October 7, 1946, in Jersey City, New Jersey[1]) is an American biochemist and physician-scientist. He was the deputy director (Intramural) of the National Institutes of Health (NIH) in the United States, and also Chief of the Laboratory of Cell Biology at the National Cancer Institute (NCI) within the NIH.[2]

Career

He graduated summa cum laude in biochemical sciences in 1966 from Harvard College, and received his M.D. magna cum laude from Harvard Medical School in 1970.[1] He then worked as an intern and resident at the Peter Dent Brigham Hospital in Boston, a research associate at the NIH, and an assistant professor at Harvard before taking a permanent position at the NIH in 1976.[1] On August 1, 2022, Gottesman was succeeded as director of the NIH Intramural Research Program by pediatric neurologist Nina F. Schor.[3]

Research

His areas of expertise includes a major contribution to the discovery of P-glycoprotein (MDR1, ABCB1), the multidrug resistance efflux transporter associated with clinical resistance to anti-cancer agents.[4] [5] In 2007, he reported for the first time in Science magazine that silent polymorphisms can impact on the tertiary structure and function of a protein.[6]

Distinctions

Gottesman is an elected member of the American Association for the Advancement of Science (1988), the National Academy of Medicine (2003), the Association of American Physicians (2006), the American Academy of Arts and Sciences (2010), and the National Academy of Sciences (2018).

External links

Notes and References

  1. https://orwh.od.nih.gov/pharmacology/speak.html Pharmacology Conference Speakers
  2. http://ccr.nci.nih.gov/staff/staff.asp?profileid=5713 Staff profile
  3. Web site: 2022-07-13 . Dr. Nina Schor appointed as the NIH Acting Deputy Director for Intramural Research . 2022-07-29 . National Institutes of Health (NIH) . EN.
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