Michael Elowitz Explained

Michael Elowitz
Nationality:American
Fields:Biology
Workplaces:California Institute of Technology

Howard Hughes Medical Institute
Alma Mater:University of California, BerkeleyPrinceton University
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Awards:MacArthur Fellows Program
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Michael B. Elowitz is a biologist and professor of Biology, Bioengineering, and Applied Physics at the California Institute of Technology,[1] [2] [3] and investigator at the Howard Hughes Medical Institute.[4] In 2007 he was the recipient of the Genius grant, better known as the MacArthur Fellows Program for the design of a synthetic gene regulatory network, the Repressilator, which helped initiate the field of synthetic biology.[5] He was the first to show how inherently random effects, or 'noise', in gene expression could be detected and quantified in living cells,[6] leading to a growing recognition of the many roles that noise plays in living cells. His work in Synthetic Biology and Noise represent two foundations of the field of Systems Biology. Since then, his laboratory has contributed to the development of synthetic biological circuits that perform a range of functions inside cells, and revealed biological circuit design principles underlying epigenetic memory, cell fate control, cell-cell communication, and multicellular behaviors.[7]

Career

His laboratory studies the dynamics of genetic circuits in individual living cells using synthetic biology, time-lapse microscopy, and mathematical modeling, with a particular focus on the way in which cells make use of noise to implement behaviors that would be difficult or impossible without it. Recently, his lab has expanded their approaches beyond bacteria to include eukaryotic and mammalian cells.[8]

Life

Elowitz grew up in Los Angeles, California, where he attended the humanities magnet at Alexander Hamilton High School (Los Angeles). He studied Physics and graduated with a B.A. from the University of California, Berkeley in 1992, and from Princeton University with a Ph.D. in 1999.[9] In 1997–1998, he spent one year at the European Molecular Biology Laboratory at Heidelberg.Afterwards, he was a postdoctoral fellow at the Rockefeller University in New York City.

While working as a graduate student at Princeton he co-authored songs such as Sunday at the Lab[10] with Uri Alon.

Awards

Peer-reviewed publications

External links

Notes and References

  1. Web site: The Elowitz Lab [Caltech]]. www.elowitz.caltech.edu.
  2. Web site: Biology Division - Michael Elowitz . March 27, 2010 . dead . https://web.archive.org/web/20100624171119/http://biology.caltech.edu/Members/Elowitz . June 24, 2010 . dmy-all .
  3. Web site: Caltech Applied Physics - Not Found. www.aph.caltech.edu.
  4. Web site: Michael B. Elowitz, PhD - HHMI.org.
  5. Ten years of synergy. January 1, 2010. Nature. 463. 7279. 269–270. 10.1038/463269b. 20090703. 2010Natur.463R.269.. free.
  6. Web site: Database of Cell Signaling and Virtual Journal - Science Signaling. stke.sciencemag.org.
  7. Web site: https://www.elowitz.caltech.edu/.
  8. http://www.hhmi.org/research/investigators/elowitz.html "Gene Circuit Dynamics in Regulation and Differentiation", Howard Hughes Medical Institute
  9. Web site: Searle Scholars Program : 2007 News Archive. www.searlescholars.net.
  10. https://www.youtube.com/watch?v=yhncg6GXYq8 Sunday at the Lab performed by Uri Alon
  11. Web site: 2022 NAS Election . 2022-08-28 . www.nasonline.org.
  12. Web site: Three from Caltech Elected as AAAS Fellows . November 22, 2016 .
  13. Web site: 2011 HFSP Nakasone Award goes to Michael Elowitz - Human Frontier Science Program. www.hfsp.org.
  14. [Presidential Early Career Award for Scientists and Engineers]
  15. Web site: 20 Best Brains Under 40 - DiscoverMagazine.com.
  16. Web site: Michael Elowitz - MacArthur Foundation . May 13, 2019 . https://web.archive.org/web/20120315021556/http://www.macfound.org/site/c.lkLXJ8MQKrH/b.2913825/apps/nl/content2.asp?content_id=%7BB319FBF7-A99D-48DB-9293-3CF3434EC3C2%7D&notoc=1 . March 15, 2012 . dead . mdy-all .
  17. Web site: Elowitz, Michael - The David and Lucile Packard Foundation.
  18. TR35 winners
  19. Web site: Burroughs Wellcome Fund: Dr. Michael Elowitz . March 27, 2010 . dead . https://web.archive.org/web/20110725112221/https://forms.bwfund.org/news/awardee_profiles/michael_elowitz.html . July 25, 2011 . dmy-all .
  20. Li. Pulin. Markson. Joseph S.. Wang. Sheng. Chen. Siheng. Vachharajani. Vipul. Elowitz. Michael B.. April 5, 2018. Morphogen gradient reconstitution reveals Hedgehog pathway design principles. Science. 360. 6388. en. 543–548. 10.1126/science.aao0645. 0036-8075. 29622726. 6516753. 2018Sci...360..543L.
  21. Dynamics of epigenetic regulation at the single-cell level. Science. February 12, 2016. 0036-8075. 720–724. 351. 6274. 10.1126/science.aab2956. 26912859. en. Lacramioara. Bintu. John. Yong. Yaron E.. Antebi. Kayla. McCue. Yasuhiro. Kazuki. Narumi. Uno. Mitsuo. Oshimura. Michael B.. Elowitz. 5108652. 2016Sci...351..720B.
  22. Combinatorial gene regulation by modulation of relative pulse timing. Nature. 10.1038/nature15710. Yihan. Lin. Chang Ho. Sohn. Chiraj K.. Dalal. Long. Cai. Michael B.. Elowitz. 527. 7576. 54–58. 26466562. 4870307. 2015. 2015Natur.527...54L.

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