| Muhammad Ghulam Shah Kalhoro | |
| Native Lang1 Name1: | محمد غلام شاه ڪلهوڙو |
| Shah Wardi Khan Mian | |
| Succession: | 3rd Nawab of Sindh |
| Reign: | 8 August 1758 – 1772 |
| Predecessor: | Muhammad Muradyab Khan |
| Successor: | Muhammad Sarfraz Kalhoro |
| Issue: | Mian Muhammad Sarfraz Khan |
| Full Name: | Mian Muhammad Ghulam Shah Kalhoro |
| House: | Kalhora |
| Dynasty: | Kalhora dynasty |
| Father: | Noor Mohammad Kalhoro |
| Mother: | Mai Gulan |
| Birth Date: | 1724 |
| Death Date: | 1772 (aged 48) |
| Death Place: | Hyderabad, Sindh State |
| Place Of Burial: | Hyderabad |
| Religion: | Sunni Islam |
Mian Muhammad Ghulam Shah Kalhoro (died 1772) Sindhi: مياں محمد غلام شاه ڪلهوڙو ) was a member of the Kalhora dynasty who, in 1758, was enthroned as the 3rd Nawab of Sindh by tribal Chiefs of Kalhora, replacing his brother Mian Muradyab Kalhoro. He was recognized and bestowed upon title of Shah Wardi Khan by the Afghan emperor Ahmad Shah Durrani.
He was able to bring stability in Sindh after the rule of Noor Mohammad Kalhoro; he reorganized the country and defeated the Marathas and their permanent vassal the Rao of Kutch near the Thar Desert and returned victoriously. Ghulam Shah also ordered construction of the Shrine of Shah Abdul Latif Bhittai.[1] The tomb of Ghulam Shah Kalhoro is situated in Hyderabad, Sindh.[2]