MiRBase explained

miRBase
Description:microRNA database
Center:University of Manchester
Author:Ana Kozomara
Citation:Kozomara & al. (2011)
Released:2010

In bioinformatics, miRBase is a biological database that acts as an archive of microRNA sequences and annotations.[1] [2] [3] [4] As of September 2010 it contained information about 15,172 microRNAs. This number has risen to 38,589 by March 2018.[5] The miRBase registry provides a centralised system for assigning new names to microRNA genes.[6]

miRBase grew from the microRNA registry resource set up by Sam Griffiths-Jones in 2003.[7]

According to Ana Kozomara and Sam Griffiths-Jones miRBase has five aims:[1]

  1. To provide a consistent naming system for microRNAs
  2. To provide a central place collecting all known microRNA sequences
  3. To provide human and computer readable information for each microRNA
  4. To provide primary evidence for each microRNA
  5. To aggregate and link to microRNA target information

MiRBase contains miRNAs belonging of various species belonging to Alveolata, Chromalveolata, Metazoa, Mycetozoa, Viridiplantae and Viruses. For the Viridiplantae, in release 21 (2014) data is available for 73 species. This includes 4800 unique mature miRNAs and 8480 precursor sequences.[8]

The current version of MiRBase is release 22 (March 2018).

External links

Notes and References

  1. Kozomara . A. . Griffiths-Jones . S. . MiRBase: integrating microRNA annotation and deep-sequencing data . Nucleic Acids Research . 39 . Database issue . D152–7 . 2010 . 21037258 . 3013655 . 10.1093/nar/gkq1027.
  2. Book: Griffiths-Jones . Sam . Current Protocols in Bioinformatics . Chapter 12 . MiRBase: microRNA Sequences and Annotation . Unit 12.9.1–10 . 2010 . 10.1002/0471250953.bi1209s29. 20205188 . 978-0471250951 . 19303675 .
  3. Griffiths-Jones . S. . Saini . H. K. . Van Dongen . S. . Enright . A. J. . MiRBase: tools for microRNA genomics . Nucleic Acids Research . 36 . Database issue . D154–8 . 2007 . 17991681 . 2238936 . 10.1093/nar/gkm952.
  4. Book: Griffiths-Jones . Sam . MicroRNA Protocols . Methods in Molecular Biology . MiRBase: the MicroRNA Sequence Database . 342 . 129–38 . 2006 . 10.1385/1-59745-123-1:129. 16957372 . 1-59745-123-1 .
  5. Web site: [ftp://mirbase.org/pub/mirbase/CURRENT/README Mirbase 22 Release Notes].
  6. Griffiths-Jones . S. . Grocock . RJ . Van Dongen . S . Bateman . A . Enright . AJ . MiRBase: microRNA sequences, targets and gene nomenclature . Nucleic Acids Research . 34 . Database issue . D140–4 . 2006 . 16381832 . 1347474 . 10.1093/nar/gkj112.
  7. Griffiths-Jones S . The microRNA Registry . Nucleic Acids Res. . 32 . Database issue . D109–11 . January 2004 . 14681370 . 308757 . 10.1093/nar/gkh023 .
  8. Nithin. Chandran. Thomas. Amal. Basak. Jolly. Bahadur. Ranjit Prasad. 2017-11-15. Genome-wide identification of miRNAs and lncRNAs in Cajanus cajan. BMC Genomics. 18. 1. 878. 10.1186/s12864-017-4232-2. 29141604. 5688659. 1471-2164 . free .

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