MiR-208 explained
| miR-208 |
| Symbol: | miR-208 |
| Altsymbols: | MIR208 |
| Rfam: | RF00749 |
| Mirbase: | MI0000251 |
| Mirbase Family: | MIPF0000178 |
| Rna Type: | miRNA |
| Tax Domain: | Metazoa |
| Go: | 0035195 |
| So: | 0001244 |
| Entrezgene: | 406990 |
| Hgncid: | 31585 |
| Omim: | 611116 |
| Refseq: | NR_029595 |
| Chromosome: | 14 |
| Arm: | q |
| Band: | 11.2 |
miR-208 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]
In humans, the gene for miR-208 is located in an intron of MYH7.[3]
Function
miR-208 has been deemed a "myomiR" as it is specifically expressed, or found at much higher levels, in cardiac tissue. Other myomiRs include miR-1 and miR-133. miR-208 is thought to be dysregulated in various cardiovascular diseases.[4] [5]
miR-208 functions in cardiomyocytes regulating the production of the myosin heavy chain during development. It also responds to stress and forms part of a hormonal signalling cascade in cardiac cells.[6]
Applications
A preliminary study has shown a potential use in the prognosis of dilated cardiomyopathy.[7] Another application has been suggested as using plasma concentration of miR-208 as a biomarker of damaged cardiac muscle cells.[8]
Further reading
- Kukreja RC, Yin C, Salloum FN . MicroRNAs: new players in cardiac injury and protection . Molecular Pharmacology . 80 . 4 . 558–64 . October 2011 . 21737570 . 3187527 . 10.1124/mol.111.073528 .
Notes and References
- Ambros V . microRNAs: tiny regulators with great potential . Cell . 107 . 7 . 823–6 . December 2001 . 11779458 . 10.1016/S0092-8674(01)00616-X . free .
- Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R . Human RISC couples microRNA biogenesis and posttranscriptional gene silencing . Cell . 123 . 4 . 631–40 . November 2005 . 16271387 . 10.1016/j.cell.2005.10.022 . free .
- Malizia AP, Wang DZ . MicroRNAs in cardiomyocyte development . Wiley Interdisciplinary Reviews: Systems Biology and Medicine . 3 . 2 . 183–90 . Mar–Apr 2011 . 21305703 . 3058499 . 10.1002/wsbm.111 .
- Cai B, Pan Z, Lu Y . The roles of microRNAs in heart diseases: a novel important regulator . Current Medicinal Chemistry . 17 . 5 . 407–11 . 2010 . 20015039 . 10.2174/092986710790226129 .
- Han M, Toli J, Abdellatif M . MicroRNAs in the cardiovascular system . Current Opinion in Cardiology . 26 . 3 . 181–9 . May 2011 . 21464712 . 10.1097/HCO.0b013e328345983d . 205620160 .
- van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN . Control of stress-dependent cardiac growth and gene expression by a microRNA . Science . 316 . 5824 . 575–9 . April 2007 . 17379774 . 10.1126/science.1139089 . 2007Sci...316..575V . 1927839 .
- Satoh M, Minami Y, Takahashi Y, Tabuchi T, Nakamura M . Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy . Journal of Cardiac Failure . 16 . 5 . 404–10 . May 2010 . 20447577 . 10.1016/j.cardfail.2010.01.002 .
- Ji X, Takahashi R, Hiura Y, Hirokawa G, Fukushima Y, Iwai N . Plasma miR-208 as a biomarker of myocardial injury . Clinical Chemistry . 55 . 11 . 1944–9 . November 2009 . 19696117 . 10.1373/clinchem.2009.125310 .
