MiR-191 explained
| miR-191 |
| Symbol: | miR-191 |
| Altsymbols: | MIR191 |
| Rfam: | RF00764 |
| Mirbase: | MI0000465 |
| Mirbase Family: | MIPF0000194 |
| Rna Type: | miRNA |
| Tax Domain: | Mammalia |
| Go: | 0035195 |
| So: | 0001244 |
| Entrezgene: | 406966 |
| Hgncid: | 31561 |
| Refseq: | NR_029690 |
| Chromosome: | 3 |
| Arm: | p |
| Band: | 21.31 |
miR-191 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]
miR-191 has been found to be dysregulated in many types of human tumour, including those of colorectal,[3] breast and prostate cancers.[4] Despite these cancer links, target genes of the mature miRNA have not been characterised, and it is not known which factors lead to its dysregulation in certain tumour cells.[5]
The expression profile of miR-191 could be implemented in prognosis of acute myeloid leukaemia, with higher than average levels of miR-191 suggesting a lower survival probability.[6]
Notes and References
- Ambros V . microRNAs: tiny regulators with great potential . Cell . 107 . 7 . 823–6 . Dec 2001 . 11779458 . 10.1016/S0092-8674(01)00616-X . 14574186 . free .
- Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R . Human RISC couples microRNA biogenesis and posttranscriptional gene silencing . Cell . 123 . 4 . 631–40 . Nov 2005 . 16271387 . 10.1016/j.cell.2005.10.022 . 16973870 . free .
- Xi Y, Formentini A, Chien M, Weir DB, Russo JJ, Ju J, Kornmann M, Ju J . Prognostic Values of microRNAs in Colorectal Cancer . Biomarker Insights . 2 . 113–121 . 2006 . 18079988 . 2134920 .
- Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM . A microRNA expression signature of human solid tumors defines cancer gene targets . Proceedings of the National Academy of Sciences of the United States of America . 103 . 7 . 2257–61 . Feb 2006 . 16461460 . 1413718 . 10.1073/pnas.0510565103 . 2006PNAS..103.2257V . free .
- Shen J, DiCioccio R, Odunsi K, Lele SB, Zhao H . Novel genetic variants in miR-191 gene and familial ovarian cancer . BMC Cancer . 10 . 47 . 2010-02-18 . 20167074 . 2831822 . 10.1186/1471-2407-10-47 . free .
- Garzon R, Volinia S, Liu CG, Fernandez-Cymering C, Palumbo T, Pichiorri F, Fabbri M, Coombes K, Alder H, Nakamura T, Flomenberg N, Marcucci G, Calin GA, Kornblau SM, Kantarjian H, Bloomfield CD, Andreeff M, Croce CM . MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia . Blood . 111 . 6 . 3183–9 . Mar 2008 . 18187662 . 2265455 . 10.1182/blood-2007-07-098749 .
