| Mezilesí | |
| Settlement Type: | Municipality |
| Subdivision Type: | Country |
| Subdivision Type1: | Region |
| Subdivision Name1: | Hradec Králové |
| Subdivision Type2: | District |
| Subdivision Name2: | Náchod |
| Pushpin Map: | Czech Republic |
| Pushpin Relief: | 1 |
| Pushpin Map Caption: | Location in the Czech Republic |
| Coordinates: | 50.3561°N 16.2169°W |
| Established Title: | First mentioned |
| Established Date: | 1403 |
| Area Total Km2: | 2.36 |
| Elevation M: | 504 |
| Population As Of: | 2024-01-01 |
| Population Footnotes: | [1] |
| Population Total: | 251 |
| Population Density Km2: | auto |
| Timezone1: | CET |
| Utc Offset1: | +1 |
| Timezone1 Dst: | CEST |
| Utc Offset1 Dst: | +2 |
| Postal Code Type: | Postal code |
| Postal Code: | 549 23 |
Mezilesí (German: Metzles) is a municipality and village in Náchod District in the Hradec Králové Region of the Czech Republic. It has about 300 inhabitants.