Mexrenone Explained

Mexrenone (code names ZK-32055, SC-25152) is a steroidal antimineralocorticoid of the spirolactone group related to spironolactone that was never marketed.^{[1] [2]} It is the lactonic form of mexrenoic acid (mexrenoate), and mexrenoate potassium (SC-26714), the potassium salt of mexrenoic acid, also exists.^[3] In addition to the mineralocorticoid receptor, mexrenone also binds to the glucocorticoid, androgen, and progesterone receptors.^[4] Relative to spironolactone, it has markedly reduced antiandrogen activity (approximately one-tenth of the antimineralocorticoid dosage equivalent antiandrogen activity of spironolactone). Eplerenone is the 9-11α-epoxy analogue of mexrenone.^[5]

See also

• Canrenone
• Mexrenoate potassium
• Mexrenoic acid
• Potassium canrenoate
• Prorenone

Notes and References

1. Cutler GB, Pita JC, Rifka SM, Menard RH, Sauer MA, Loriaux DL . SC 25152: A potent mineralocorticoid antagonist with reduced affinity for the 5 alpha-dihydrotestosterone receptor of human and rat prostate . The Journal of Clinical Endocrinology and Metabolism . 47 . 1 . 171–175 . July 1978 . 263288 . 10.1210/jcem-47-1-171 .
2. Cutler GB, Sauer MA, Loriaux DL . SC 25152: a potent mineralocorticoid antagonist with decreased antiandrogenic activity relative to spironolactone . The Journal of Pharmacology and Experimental Therapeutics . 209 . 1 . 144–146 . April 1979 . 430374 .
3. Hofmann LM, Weier RM, Suleymanov OD, Pedrera HA . Mexrenoate potassium: a steroidal aldosterone antagonist and antihypertensive . The Journal of Pharmacology and Experimental Therapeutics . 201 . 3 . 762–768 . June 1977 . 864608 .
4. Book: Szasz G, Budvari-Barany Z . Pharmaceutical Chemistry of Antihypertensive Agents. 19 December 1990. CRC Press. 978-0-8493-4724-5. 87–.
5. Ménard J . The 45-year story of the development of an anti-aldosterone more specific than spironolactone . Molecular and Cellular Endocrinology . 217 . 1–2 . 45–52 . March 2004 . 15134800 . 10.1016/j.mce.2003.10.008 . 19701784 .